Pfeiffer’s Glandular Fever (Infectious Mononucleosis): Causes

Pathogenesis (disease development)

After Epstein-Barr virus (human herpes virus 4; HHV 4) is transmitted via droplet or smear infection, it first infects cells in the mouth and throat.

The body of an immunocompetent person can destroy most of the virus, but a few of the infected cells survive and can lead to reinfection (re-infection) and secondary disease if the affected person is immunosuppressed.

Etiology (causes)

Biographic causes

  • Socioeconomic factors – in areas with low socioeconomic standards, infection occurs in childhood