Zollinger-Ellison Syndrome: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90).

  • Diabetes mellitus

Skin and subcutaneous tissue (L00-L99)

  • Vitiligo (white spot disease)

Mouth, esophagus (food pipe), stomach, and intestines (K00-K67; K90-K93).

  • Small intestinal stenosis – narrowing of the small intestine.
  • Gastritis (inflammation of the gastric mucosa)
  • Gastric outlet stenosis – narrowing of the gastric outlet.

Musculoskeletal system and connective tissue (M00-M99).

  • Rheumatoid arthritis

Neoplasms – tumor diseases (C00-D48)

Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99).

  • Renal insufficiency (kidney weakness).

Injuries, poisoning, and other consequences of external causes (S00-T98).

Medications that may cause hypergastrinemia (gastrin level > 100 pg/ml):

  • H2-blockers, H2-receptor antagonists are antihistaminesdrugs used to inhibit gastric acid secretion in peptic ulcers (gastric ulcers), gastric acid hypersecretion and secondary syndromes (reflux).
  • Proton pump inhibitors (PPIs; acid blockers) – medications such as omeprazole that are used to treat gastric ulcers (stomach ulcers)