Abdominal Pain: Drug Therapy

Therapy goals

  • Symptomatic therapy
  • Diagnosis finding

Therapy recommendations

  • Acute abdominal pain: analgesia (pain management) according to WHO staging scheme until definitive therapy when diagnosis is confirmed:
    • Non-opioid analgesic: paracetamol, first-line agent for acute abdominal pain.
    • Low-potency opioid analgesic (e.g., tramadol) + non-opioid analgesic.
    • High-potency opioid analgesic (eg, morphine) + non-opioid analgesic.

    If necessary, butylscopolamine (spasmolytic).

  • Chronic abdominal pain: analgesia according to WHO staging scheme until definitive therapy when diagnosis is confirmed:
    • Non-opioid analgesic: metamizoleNote: In chronic abdominal pain, do not administer acetaminophen (because of hepatotoxicity!) and coxibe (potential cardiac side effects).
    • Low-potency opioid analgesic (eg, tramadol) + non-opioid analgesic: caveat for constipation!
    • High-potency opioid analgesic (e.g., morphine) + non-opioid analgesic.

    If necessary, butylscopolamine (spasmolytic).

  • Neuropathic pain – opioid analgesics, anticonvulsants, antidepressants(treatment option for 4-12 weeks); in patients with neuropathic tumor pain who respond only partially to opioid analgesics, amitriptyline, gabapentin, or pregabalin should be considered.
  • Infantile colic/infantile colic (“three-month colic”):