Active ingredient and effect of Fenistil® Gel
The active ingredient of Fenistil® gel is called Dimetinden. It is an H1-receptor antagonist. This means that dimetinden binds to the H1 receptors and thus these binding sites are no longer accessible to histamine.
If histamine can no longer bind to the receptors, the H1 receptors are not activated either. The H1 receptors have different effects depending on the organ in which they are found. In vessels, activation of the H1 receptors causes an increase in vascular permeability and dilatation of the vessels.
Vascular permeability describes the permeability of the vessel wall of our veins. If the permeability is increased, more fluid from the blood enters the surrounding tissue and swelling occurs. This effect is due to the activation of the H1-receptors by histamine.
If dimetindens in the form of Fenistil® gel are used, the H1 receptor is blocked and vascular permeability is reduced again. The swelling then goes down. In addition, the vessels are no longer dilated, which reduces the resulting redness and heat. In addition, the activation of the H1 receptor causes itching and an increased sensation of pain. In this case, the receptor can also be blocked with dimetinden, so that itching and pain are reduced.
Side effect of Fenistil® Gel
Interactions with other drugs are not yet known. As long as the gel has been used as intended, i.e. only applied to a small area of the skin, no interactions are to be feared. The situation is different with the systemic intake, for example as drops or infusions, of Dimetinden.
Here the simultaneous use of tricyclic antidepressants is a risk factor. However, since Fenistil® Gel does not have a systemic effect, there are no interactions to consider. In this respect it is also advisable not to apply the gel to open wounds, since it penetrates over it into the bloodstream.
Dosage
If you have skin symptoms, you should apply Fenistil® Gel up to 3 times a day to the affected area. The gel should be applied in a thin layer and then lightly rubbed in. Bandages are not recommended for use.
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