Products
Nasal sprays containing beclomethasone dipropionate have been approved in many countries since 1998 (Otri Hay Fever, formerly Beconase).
Structure and properties
The active ingredient beclometasone is present in the drug as beclometasone dipropionate (C24H32O4, Mr = 384.5 g/mol) is present, a white crystalline powder that is practically insoluble in water.
Effects
Beclomethasone dipropionate (ATC R01AD01) has antiallergic, anti-inflammatory, and immunosuppressive properties. The effects are due to binding to intracellular glucocorticoid receptors in the cytoplasm of cells. The resulting complex interacts with DNA. Full efficacy is achieved after a few days.
Indications
For the treatment of hay fever (seasonal allergic rhinitis) in adults over 18 years of age.
Dosage
According to the SmPC.
- The spray should be administered regularly to achieve full effect.
- Shake before use.
- Adults over 18 years either give 2 doses in each nostril in the morning and evening or 1 dose in each nostril three to four times daily.
- Do not overdose.
See also under administering nasal sprays.
Contraindications
Beclometasone nasal spray is contraindicated in hypersensitivity. For complete precautions, see the drug label.
Interactions
There are no known drug-drug interactions.
Adverse effects
The most common possible adverse effects include nosebleeds, dryness and irritation of the nasal mucosa and throat, and an unpleasant taste and odor.
