Binet classification of chronic lymphocytic leukemia (CLL).
| Binet stage | Number of lymph node stations affected | Hemoglobin (Hb) | Platelets |
| A | < 3 | ≥ 10 g/dl | ≥ 100,000 /μl |
| B | ≥ 3 | ≥ 10 g/dL | ≥ 100,000 /μl |
| C | irrelevant | <10 g/dL | or < 100,000 /μl |
The International Prognostic Index (CLL-IPI).
| Independent factor | Score |
| del17p and/or TP53 mutation | 4 |
| Serum β2-microglobulin > 3.5 mg/l | 2 |
| IgHV unmutated | 2 |
| clinical stage Binet B/C or Rai I-IV | 1 |
| Age > 65 years | 1 |
Legend: IgHV = immunoglobulin heavychain variableregion gene.
5-year survival rate as a function of risk classification according to CLL-IPI.
| Risk category | Total | 5-year survival rate |
| “low risk” | 0-1 | 93,2 % |
| “intermediate” | 2-3 | 79,3 % |
| “high” | 4-6 | 63,3 % |
| “very high” | 7-10 | 23,3 % |
Legend: CLL = chronic lymphocytic leukemia; IPI = International Prognostic Index.
Special forms of chronic lymphocytic leukemia (CLL):
- Leukemic non-Hodgkin’s lymphoma (rare).
- Monoclonal B-cell lymphocytosis (MBL): lymphocyte count in the blood is less than 5,000/µl (in contrast to CLL: lymphocyte count > 5,000/µl). (Relatively common) MBL may later develop into CLL.
- Prolymphocytic leukemia (PLL): in the blood and lymphoid tissue predominate prolymphocytes (> 55% of all lymphocytes).
- Richter transformation (special form of CLL), in which chronic leukemia develops into an aggressive lymphoma.
