Conn Syndrome: Complications

The following are the most important diseases or complications that may be contributed to by Conn syndrome:

Endocrine, nutritional, and metabolic diseases (E00-E90).

Cardiovascular system (I00-I99)

  • Apoplexy (stroke)
  • Hypertension (high blood pressure)-manifestation in the classic constellation of hypertension and spontaneous hypokalemia (potassium deficiency); also frequently seen as normokalemic hypertension (most common cause of secondary hypertension)
    • A study included a total of 1,672 primary care patients with hypertension (569 newly diagnosed and 1,103 patients previously diagnosed with arterial hypertension:
      • 99 patients (5.9%) were diagnosed with primary hyperaldosteronism (PA; Conn syndrome)
      • Overall prevalence (disease incidence) of PA increased with severity of hypertension, from 3.9% in stage I to 11.8% in stage III hypertension
  • Cardiovascular damage, unspecified.
  • Myocardial infarction (heart attack)
  • Atrial fibrillation (VHF)

Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99)

  • Proteinuria (increased excretion of protein in the urine).
  • Renal failure

Further

  • Impaired glucose tolerance (ability of the body to break down a large amount of glucose without the development of pathological blood glucose or urine sugar levels; body cells respond less well to the hormone insulin).