Osteosarcoma: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests.

  • Biopsy (tissue sample) – to determine the type of tumor as well as its aggressiveness; most important diagnostic measure in cases of suspected tumor; performed following imaging procedures (see “Medical Device Diagnostics“)Caveat: When performing this procedure, possible effects on the upcoming tumor resection and subsequent reconstruction must be considered.
  • Alkaline phosphatase (AP) isoenzymes, ostase, urinary calcium (tumor hypercalcemia (synonym: tumor-induced hypercalcemia, TIH) is one of the most common symptoms in paraneoplastic syndromes), PTHrP (parathyroid hormone-related protein; the constellation with decreased parathyroid hormone (PTH) and increased PTHrP is typical for tumor hypercalcemia).
  • Inflammatory parameters – CRP (C-reactive protein) or ESR (erythrocyte sedimentation rate).
  • Wg. possible anemia (anemia): small blood count, ferritin * , folic acid, vitamin B12, reticulocytes.

* Low ferritin levels may be “masked” by inflammatory responses. Therefore, the assessment of ferritin should be performed in parallel with C-reactive protein (acute phase protein), if necessary.