Product
Cyclizine has been discontinued in many countries since 2008. Marzine is no longer available. Possible alternatives include the antihistamines dimenhydrinate or meclozine.
Structure and properties
Cyclizine (C18H22N2, Mr = 266.38 g/mol) is a piperazine derivative. In the drug, it is present as cyclizine hydrochloride.
Effects
Cyclizine (ATC R06AE03) has antihistamine, antiemetic, antivertiginous, and sedative properties.
Indications
- Motion sickness
- Nausea, vomiting
- Dizziness
- Allergy, hay fever
Cyclicin was among the first antihistamines and was used by NASA during the moon flight as an antiemetic.
