Pathogenesis (disease development)
The etiology (causes) of eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome (CSS), is unknown. Genetic factors, the complement system, B- and T-cell response, involvement of cytokines, and endothelial changes are thought to be important with regard to pathogenesis. Infectious triggers are also discussed as triggers. Neutrophils, B cells, and ANCA (antineutrophil cytoplasmic antibodies) are at the forefront of the pathogenesis of ANCA-associated vasculitides.
Etiology (Causes)
Disease-related causes
Medications
- Montelukast is discussed as a triggering agent
