Hashimoto’s Thyroiditis: Complications

The following are the most important diseases or complications that may be contributed to by Hashimoto’s thyroiditis:

Respiratory system (J00-J99)

Endocrine, nutritional, and metabolic diseases (E00-E90).

  • Hypothyroidism (underactive thyroid; manifest or latent); rate of progression from latent to definite hypothyroidism
    • In patients with exclusively elevated TSH: 2.9% per year.
    • In patients with elevated TSH and elevated TPO antibody levels: 4.0% per year.
  • Myxedema – pasty (puffy; bloated) skin showing nonpushable, doughy edema (swelling) that is not positional; facial and peripheral; occurring primarily on the lower legs

Skin and subcutaneous (L00-L99).

  • Alopecia (diffuse hair loss)

Cardiovascular system (I00-I99)

Neoplasms – tumor diseases (C00-D48)

  • Thyroid carcinoma

Ears – mastoid process (H60-H95)

  • Hearing loss

Psyche – nervous system (F00-F99; G00-G99)

  • Anxiety disorders
  • Dementia
  • Depression
  • Hashimoto’s encephalopathy – changes in the brain likely related to Hashimoto’s thyroiditis.
  • Carpal tunnel syndrome – compression syndrome of the median nerve in the region of the carpus.
  • Concentration disorders
  • Paresthesias (insensations)
  • Psychosis
  • Cerebellar ataxia (gait disorder)

Symptoms and abnormal clinical and laboratory parameters, not elsewhere classified (R00-R99).

  • Muscle spasms
  • Muscle pain
  • Muscle stiffness

Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99)

  • Menorrhagiamenstruation is prolonged (> 6 days) and increased.
  • Oligomenorrhea (the interval between periods is > 35 days and ≤ 90 days, i.e., periods occur too infrequently); secondary amenorrhea (no menstrual bleeding for > 90 days)