To prevent oxidative or nitrosative stress, attention must be paid to reducing individual risk factors. Behavioral risk factors Diet Malnutrition and undernutrition – including over- and undernutrition. Diet low in micronutrients (few cereal products, less than 5 servings of vegetables and fruits (< 400 g/day; 3 servings of vegetables and 2 servings of fruits), few … Oxidative Stress and Nitrosative Stress: Prevention
Oxidative stress is a biochemical condition that has no clear symptoms!Risk factors are thus the first indication of possible oxidative stress.However, detection of oxidative or nitrosative stress is only possible by laboratory diagnosis.
Pathogenesis (disease development) Oxidative or nitrosative stress occurs when cellular antioxidant defenses are too low to compensate for reactive oxygen radicals: As intermediates of metabolism, free radicals are constantly produced in every cell of the human body. The oxygen compounds with unpaired electrons strive to snatch electrons from another atom or molecule. They react with … Oxidative Stress and Nitrosative Stress: Causes
General measures Nicotine restriction (refraining from tobacco use). Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Aim for normal weight!Determination of BMI (body mass index, body mass index) or body composition using electrical impedance analysis. BMI ≥ 25 → participation in a medically supervised weight loss … Oxidative Stress and Nitrosative Stress: Therapy
Medical history (history of illness) represents an important component in the diagnosis of oxidative stress. Family history Social history What is your occupation? Do you work physically hard? Is there any evidence of psychosocial stress or strain due to your family situation? Current medical history/systemic history (somatic and psychological complaints). What complaints have you noticed? … Oxidative Stress and Nitrosative Stress: Medical History
Modern laboratory diagnostics enable both early detection of diseases and timely therapy, thus contributing to your health. A simple blood test can provide certainty about the balance between oxidative free radical load and antioxidant potential: d-ROMs test: oxidative stress test. The d-ROMs test indicates the level of free radical exposure and provides information about the … Oxidative Stress: Antioxidant Test, d-ROM Test and BAP Test
The following are the major sequelae that may be contributed to by oxidative stress or nitrosative stress: Oxidative stress has effects on: Mitochondria (“power plants of the cells”) (see below for nitrosative stress). Enzymes (“metabolic accelerators”; enzymes of the citric acid cycle, the respiratory chain, and biotin synthase, which have iron as a cofactor, lose … Oxidative Stress and Nitrosative Stress: Complications
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination-including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin, mucous membranes and sclerae (white part of the eye). Auscultation (listening) of the heart. Auscultation of the lungs Palpation (palpation) of the abdomen (abdomen) (tenderness?, knocking pain?, coughing pain?, defensive … Oxidative Stress and Nitrosative Stress: Examination
