Products Certoparin was commercially available as a solution for injection (Sandoparin, off label). It was approved in many countries from 1989 to 2018. Structure and properties Certoparin is present in drugs as certoparin sodium. Effects Certoparin (ATC B01AB01) has antithrombotic properties. The effects are primarily due to inhibition of coagulation factor Xa by complexation with … Certoparin
Products Betrixaban was approved in the United States in 2017 in capsule form (Bevyxxa). The drug has not yet been approved in the EU (Dexxience). Structure and properties Betrixaban (C23H22ClN5O3, Mr = 451.9 g/mol) is present in the drug as betrixaban maleate. It is a pyridine and anthranilamide derivative. Effects Betrixaban has antithrombotic properties. The … Betrixaban
Products In many countries, no drugs containing warfarin are approved, and the closely related phenprocoumon (Marcoumar) is mainly used. However, warfarin is commonly used in other countries, particularly the United States, and is commercially available in tablet form (Coumadin) and other forms. It was approved in the United States in 1954. Structure and properties Warfarin … Warfarin
Products Acetylsalicylic acid is commercially available in the low dosage of 100 mg in the form of enteric-coated film-coated tablets (Aspirin Cardio, generics; in Germany and Austria, Aspirin Protect). The drug has been approved in many countries since 1992. Aspirin Cardio 300 mg is also used. In the United States, drugs with 81 mg (= … Acetylsalicylic Acid 100 mg
Products Acenocoumarol is commercially available in tablet form (Sintrom, Sintrom mitis). It has been approved in many countries since 1955. Structure and properties Acenocoumarol (C19H15NO6, Mr = 353.3 g/mol) is a 4-hydroxycoumarin derivative. It is present in the drug as a racemate. Effects Acenocoumarol (ATC B01AA07) has anticoagulant and antithrombotic properties. The effects are due … Acenocoumarol
Products Phenprocoumon is commercially available in tablet form (Marcoumar). It has been approved in many countries since 1953. Warfarin (Coumadin) is more common in some countries. Structure and properties Phenprocoumon (C18H16O3, Mr = 280.32 g/mol) is a derivative of 4-hydroxycoumarin and a racemate. The -enantiomer is pharmacologically more active. Phenprocoumon exists as a fine, white, … Phenprocoumon
Products Tenecteplase is commercially available as an injectable (metalysis). The drug has been approved in many countries since 2000. Structure and properties Tenecteplase is a recombinant fibrin-specific plasminogen activator produced by biotechnological methods. The glycoprotein consists of 527 amino acids. The sequence is modified from native tissue-specific plasminogen activator (t-PA) at three sites. Effects Tenecteplase … Tenecteplase
