CGRP Receptor Antagonists

Rimegepant

Products Rimegepant was approved in the United States in 2020 in the form of meltable tablets that disintegrate in the oral cavity (Nurtec ODT). ODT stands for Orally Disintegrating Tablets. Structure and properties Rimegepant exists in the drug as rimegepant sulfate (hemisulfate and sesquihydrate), a white crystalline solid that is sparingly soluble in water. Effects … Rimegepant

Ubrogepant

Products Ubrogepant was approved in the United States in 2019 in tablet form (Ubrelvy). Structure and properties Ubrogepant (C29H26F3N5O3, Mr = 549.6 g/mol) exists as a white powder that is practically insoluble in water. Effects Ubrogepant has analgesic properties and is effective against other symptoms of migraine such as photophobia (sensitivity to light), phonophobia (sensitivity … Ubrogepant