Mesalazine (5-ASA)

Introduction – What is Mesalazine? Mesalazine (trade name SalofalkĀ®) is an active ingredient from the group of so-called aminosalicylates. It has an anti-inflammatory effect and is used to treat chronic inflammatory bowel diseases. Mesalazine is the gold standard, particularly in ulcerative colitis, but it is also used in Crohn’s disease. Mesalazine is used in acute … Read more

Dosage forms of Mesalazine | Mesalazine (5-ASA)

Dosage forms of Mesalazine Mesalazine in the form of suppositories is used especially when the inflammation affects the late sections of the intestine, i.e. rectum and rectum. The suppositories, as suppositories are also called, are usually inserted rectally three times a day, in acute treatment suppositories with 500mg active substance, in prophylaxis 250mg. Mesalazine suppositories … Read more

Interaction with other drugs | Mesalazine (5-ASA)

Interaction with other drugs Mesalazine shows a variety of interactions with other drugs. Patients should inform their treating physician about taking mesalazine when prescribing a drug. Interactions may decrease the effectiveness or increase the risk of side effects. Mesalazine interacts with anticoagulants, which may be more potent. The risk of gastrointestinal bleeding is increased. Mesalazine … Read more

Contraindications – When should mesalazine not be given? | Mesalazine (5-ASA)

Contraindications – When should mesalazine not be given? Mesalazine must not be taken if there is a hypersensitivity to salicylic acid and its derivatives (this includes aspirin). Contraindications for the use of mesalazine are severe liver and kidney dysfunctions. Because of the increased risk of bleeding, mesalazine must not be used in existing stomach and … Read more

Alternatives to Mesalazine | Mesalazine (5-ASA)

Alternatives to Mesalazine In the acute phase of ulcerative colitis, mesalazine is the first choice. Patients with Crohn’s disease also show a good response to the anti-inflammatory agent. In particularly severe cases, the physician may prescribe additional cortisone at times. If there is no response to the therapy, immunosuppressive drugs are used to inhibit the … Read more