Products Rosuvastatin is commercially available in the form of film-coated tablets (Crestor, generic, auto-generic). It was approved in many countries in 2006 (Netherlands: 2002, EU and US: 2003). The marketing authorization holder is AstraZeneca. The statin was originally developed at Shionogi in Japan. In the USA, generic versions came on the market in 2016. In … Rosuvastatin
Products Ciprofibrate was commercially available in many countries in capsule form (Hyperlipen, off label). It was approved in 1993 and has not been available since 2013. Structure and properties Ciprofibrate (C13H14Cl2O3, Mr = 289.2 g/mol) is a racemate and a phenoxyisobutyric acid derivative. It exists as a white to pale yellow powder that is practically … Ciprofibrate
Products Lomitapide is commercially available in capsule form (Juxtapid, Lojuxta). It was approved in the United States in 2012 and in the EU in 2013. The drug has not yet been registered in many countries. Structure and properties Lomitapide (C39H37F6N3O2, Mr = 693.7 g/mol) is present in the drug as lomitapide mesilate, a white powder … Lomitapide
Products Fluvastatin is commercially available in the form of capsules and sustained-release generic tablets (generics). It has been approved in many countries since 1993. Sales of the original Lescol were discontinued by Novartis in 2018. Structure and properties Fluvastatin (C24H26FNO4, Mr = 411.5 g/mol) is present in drugs as fluvastatin sodium, a white or pale … Fluvastatin
Products Etofibrate is commercially available in the form of sustained-release capsules (Lipo-Merz retard). The drug is no longer registered in many countries. Structure and properties Etofibrate (C18H18ClNO5, Mr = 363.8 g/mol is a diester of clofibric acid and nicotinic acid linked via ethylene glycol. Effects Etofibrate (ATC C10AB09) is lipid-lowering. It lowers elevated cholesterol and … Etofibrate
Products Bempedoic acid was approved in the EU, the United States, and many countries in 2020 in the form of film-coated tablets (Nilemdo). The active ingredient is also combined fixed with ezetimibe (Nustendi film-coated tablets). Structure and properties Bempedoic acid (C19H36O5, Mr = 344.5 g/mol) exists as a white crystalline powder that is practically insoluble … Bempedoic Acid
Products Cerivastatin was commercially available in the form of film-coated tablets (Lipobay, Baycol). Because of rare possible adverse effects, it was withdrawn from the market in August 2001 (see below). Structure and properties Cerivastatin (C26H34FNO5, Mr = 459.6 g/mol) is a pyridine derivative and is present in drugs as cerivastatin sodium. Unlike other statins, it … Cerivastatin
Products Pitavastatin is commercially available in the form of film-coated tablets (Livazo). It was first approved in many countries in July 2012. In Japan, it has been on the market since 2003, and it is also available in other countries such as the United States and Germany. Structure and properties Pitavastatin (C25H24FNO4, Mr = 421.5 … Pitavastatin
Products Bezafibrate is commercially available in the form of sustained-release tablets (Cedur retard). It has been approved in many countries since 1979. Structure and properties Bezafibrate (C19H20ClNO4, Mr = 361.8 g/mol) lies as a white crystalline powder that is practically insoluble in water. Effects Bezafibrate (ATC C10AB02) primarily lowers elevated blood triglyceride levels. It has … Bezafibrate
Products Acipimox is commercially available in the form of capsules (Olbetam). It has been approved in many countries since 1986. Structure and properties Acipimox (C6H6N2O3, Mr = 154.1 g/mol) is a derivative of nicotinic acid, which is also active as a lipid-lowering agent. Effects Acipimox (ATC C10AD06) has lipid-lowering properties. It lowers triglycerides, cholesterol, LDL, … Acipimox
Products Simvastatin is commercially available in the form of film-coated tablets (Zocor, generics). It is also combined fixed with ezetimibe (Inegy, generic). Simvastatin has been approved in many countries since 1990. Structure and properties Simvastatin (C25H38O5, Mr = 418.6 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a … Simvastatin: Drug Effects, Side Effects, Dosage and Uses
Products Alirocumab was approved in the United States in 2015 as the first agent in the group of PCSK9 inhibitors in the form of a solution for injection (Praluent). Evolocumab (Repatha) followed as the second agent in the EU, also in 2015. Structure and properties PCSK9 inhibitors to date are monoclonal antibodies that must be … PCSK9 Inhibitors
