Hypercholesterolemia

Hyperlipoproteinemias (Disorders of Lipid Metabolism): Classification

Hyperlipoproteinemias (disorders of lipid metabolism) are divided into primary and secondary forms: Primary hyperlipoproteinemias are genetic (hereditary). Secondary hyperlipoproteinemias may occur in some diseases as a symptom of the disease (secondary phenomenon) Primary hyperlipoproteinemias Primary hyperlipoproteinemias are subdivided according to the WHO classification according to their lipoproteinemia pattern (typing according to Fredrickson/Fredrickson classification – see … Hyperlipoproteinemias (Disorders of Lipid Metabolism): Classification

Hypercholesterolemia: Surgical Therapy

Surgical therapy Liver transplantation (LTx) – for homozygous hypercholesterolemia (LDL lowering up to 80%). Partial ileum bypass (elimination of about 15% of the lower segment of the small intestine (terminal ileum) by bypass/surgical bridging) – (LDL lowering 25-38%). Portocaval shunt (PSS; vascular connection (= shunt) between the portal vein system, which collects blood from the … Hypercholesterolemia: Surgical Therapy

Hyperlipoproteinemias: Physiology

Fats ingested with food and broken down and absorbed in the intestine circulate-bound to proteins (protein)-in the blood. These proteins consist of several apoproteins (part of a protein, which consists only of amino acids), which combine with lipid fractions – consisting of cholesterol and cholesterol esters, triglycerides (TG), and phospholipids – to form the lipoproteins … Hyperlipoproteinemias: Physiology