The medical history represents an important component in the diagnosis of high growth. Family history Are there any hereditary diseases in your family? Are there other family members in your family with tall stature? Social history Current medical history/systemic history (somatic and psychological complaints). Dates of birth: Birth weight Birth length Premature birth? “small for … Tall Stature: Medical History
Congenital malformations, deformities, and chromosomal abnormalities (Q00-Q99). Homocystinuria – collective name for a group of autosomal recessive hereditary metabolic disorders that result in increased concentrations of the amino acid homocysteine in the blood and homocystine in the urine, leading to symptoms similar to Marfan syndrome. Klinefelter syndrome (XXY) – gonosomes (sex chromosomes) abnormality of the … Tall Stature: Or something else? Differential Diagnosis
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; furthermore: Inspection (viewing). Skin and mucous membranes [Klinefelter syndrome: reduced hairiness, female fat distribution]. Body proportions [Marfan syndrome: long limbs, fingers and toes?] Inspection and palpation (palpation) of the mammae (mammary glands) … Tall Stature: Examination
2nd order laboratory parameters – depending on the results of the medical history, physical examination, etc. – for differential diagnostic clarification FSH [Klinefelter syndrome: ↑↑↑] LH [Klinefelter syndrome: elevated LH levels correlate with decreased testosterone; however, these often remained elevated even after testosterone levels normalized] Somatotropic hormone (STH) (synonyms: somatotropin; English somatotropic hormone; HGH or … Tall Stature: Lab Test
Optional medical device diagnostics – depending on the results of the history, physical examination, and obligatory laboratory parameters – for differential diagnostic clarification. Skeletal maturity determination to assess bone age and to determine growth duration and expected body size. Magnetic resonance imaging of the skull (cranial MRI, cranial MRI or cMRI) – in 99% of … Tall Stature: Diagnostic Tests
The following symptoms and complaints may co-occur with High Growth: Leading symptom Height above the 97th percentile Associated symptoms Postural abnormalities Back pain Etc. (see under the respective differential diagnosis).
