Active ingredients Dosage Special features Cyclophosphamide 500 mg/m² i. v. Cyclophosphamide is a prodrug (inactive substance), which is cytotoxic only after activation in the liver. To reduce cytotoxicity, MESNA* is administered. Ifosfamide 3-5 g/m² i. v. as a 4 h/24 h infusion. Chlorambucil 0.4 mg/kg bw* * p. o., dose increase by 0.1 mg/kg bw … Cytostatic Therapy: Alkylants
Active ingredients Dosage Special features Doxorubicin 50-60 mg/m² i. v. over 30-60 minutes Cardiotoxicity (cardiac or myocardial damage) requires cardiac diagnostics for NW exclusion Daunorubicin 60 mg/m² i. v. over 2 h Daunorubicin is rapidly effective and is used primarily in induction therapy of AML* Epirubicin 100 mg/m² i. v. over 30 minutes Used especially … Cytostatic Therapy: Anthracyclines
Active ingredients Dosage (ung Special features Methotrexate 40 mg/m² i. v. over 30 minutes For use, methotrexate may be administered perorally (p. o.), intravenously (i. v.), intraarterially (i. a.), subcutaneously (s. c.), intrathecally, intravitreally, and as an intramuscular injection (i. m.). Cytarabine 100-200 mg/m² i. v. over 7 days Cytarabine is rapidly effective and is … Cytostatic Therapy: Antimetabolites
Active ingredients Dosage Special features Cisplatin 50 mg/m² i. v. over 1 h Apoptosis is induced by cisplatin, but not only in tumor cells Carboplatin AUC* 6 i. v. Apoptosis is induced by carboplatin, but not only in tumor cells Oxaliplatin 85 mg/m² i. v. over 2 h * AUC (Area under the curve) – … Cytostatic Therapy: Platinum Derivatives
Active ingredients Dosage Special features Cabazitaxel k. A. Docetaxel k. A Paclitaxel 80 mg/m² i. v. over 60 minutes Allergic reactions may be induced by paclitaxel, which must be watched for during treatment Mode of action: Taxanes act primarily on the basis of disrupting mitosis (cell division). Paclitaxel binds to β-tubulin and interferes with the … Cytostatic Therapy: Taxanes
Active ingredients Dosage Special features Irinotecan 100 mg/m² i.v. over 90 minutes Irinotecan is a prodrug (inactive substance) that is cytotoxic only after activation in the liver. Etoposide 200 mg/m² i. v. Etoposide has an allergenic effect and may lead to reduction in blood pressure Mode of action: Inhibition of topoisomerase I or II induces … Cytostatic Therapy: Topoisomerase Inhibitors
Active ingredients Dosage Special features Vinblastine 6 mg/m² (maximum 10 mg/m²) i. v. Vinca alkaloids must be administered strictly intravenously (“into the vein“). Extravasation (injection of fluid into tissue adjacent to the punctured vessel) causes severe necrosis (“tissue death”). Vincristine 1.4 mg/m² (maximum 2.0 mg absolute) i. v. Mode of action: Vinca alkaloids such as … Cytostatic Therapy: Vinca Alkaloids
