HPV Infection: Complications

The following are the most important conditions or complications that may be contributed to by human papillomavirus (HPV) infections:

Certain conditions originating in the perinatal period (P00-P96).

Neoplasms – tumor diseases (C00-D48).

Anogenital carcinomas
- Anal carcinoma (anal cancer; 5% of all malignant neoplasms of the gastrointestinal tract; incidence: 1-2 per 100,000 population per year; 90% of cases as squamous cell carcinoma; associated HPV types: HPV-16; development of anal carcinoma in over 90% of cases from persistent HPV infection) (5-year survival: approximately 66%).
- Cervical carcinoma (cervical cancer) (5-year survival rate: approximately 66%).
- Penile carcinoma (penile cancer); especially for HIV-positive men who have sex with men (MSM). (5-year survival rate: about 47%).
- Vulvar carcinoma (vulvar cancer; cancer of the external genital organs of women) (5-year survival rate: about 66%).
Malignant degeneration of skin lesions
Squamous cell carcinoma of the head and neck (KHPK).
- Oral cavity carcinoma
- Oropharyngeal carcinoma (oral pharyngeal cancer; about 80% is HPV-associated: HPV 16 (in 90%), 18, 31 (3% each; much rarer) these have a more favorable prognosis than oropharyngeal carcinomas of other etiologies; survival rates of > 90% can be achieved with smaller tumors)Radiochemotherapy (simultaneous administration of radiation treatment and chemotherapy) is a crucial therapeutic pillar in this regard. Note: More people now die from HPV-associated oropharyngeal tumors than from cervical cancer. (5-year survival rate: approximately 51%).
Squamous cell carcinoma of the lung (bronchial carcinoma), HPV16/18 infection.

Psyche – nervous system (F00-F99; G00-G99).

Pregnancy, childbirth and puerperium (O00-O99)