1st order laboratory parameters – obligatory laboratory tests.
- Human pallioma virus DNA detection (from biopsy material)HPV types are divided into two groups based on their potential to induce malignant genital disease:
- HIGH RISK types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68.
- LOW RISK types: 6, 11, 42, 43, 44
- Histological examination (from removed tissue).
- Serological HPV examination (whole blood or serum).
- HIV test (if HIV status is unknown) – for anal and genital condylomas.
Laboratory parameters 2nd order – depending on the results of the history, physical examination, etc. – for differential diagnostic clarification.
- Bacteria
- Chlamydia trachomatis (lymphogranuloma venereum) – Serology: chlamydia trachomatis,
- Neisseria gonorrhoeae (gonorrhea, gonorrhea) – genital swab for pathogen and resistance, specifically for Neisseria gonorrhoeae.
- Treponema pallidum (lues, syphilis) – antibodies against Treponema pallidum (TPHA, VDRL, etc.).
- Ureaplasma urealyticum
- Viruses
- HIV (AIDS)
- Herpes simplex virus type 1/2 (HSV type 1 u. 2)
- Fungi / parasites
- Fungi: Candida albicans et al. Candida species genital smear – pathogen and resistance.
- Trichomonas vaginalis (trichomoniasis, colpitis) – antigen detection.
Further notes
- Note: Sexual intercourse with an HPV-infected partner can deposit infected cells, free virus, or infected semen in the female genital tract without resulting in infection of the woman. Therefore, if an HPV test is performed shortly after intercourse, the result may be false-positive.
- If genital HPV infection is detected, a partner examination is required! Furthermore, screening for other sexually transmitted diseases such as HIV (human immunodeficiency virus), lues, chlamydia or hepatitis B and C is recommended.
- A 5-year screening interval for cervical cancer (cervical carcinoma) with HPV testing in women older than 30 years promises more safety than a 3-year interval with cytology.
