Kidney Stones (Nephrolithiasis): Metaphylaxis in Xanthine Stones

Therapeutic target

Prevention of stone recurrence (recurrence of urinary stones).

Therapy recommendations

Note: Xanthine stones are formed due to an autosomal recessive inherited defect of the enzyme xanthine oxidase. As a result of this condition, xanthinuria (excretion of xanthine in the urine) occurs. This leads to stone formation due to the poor solubility of xanthine in urine. Extremely rarely, xanthine stones can also be induced by drug therapy with the xanthine oxidase inhibitor allopurinol.

Nutritional therapy

  • Fluid intake > 3 l/day
  • Low purine diet

Agents or measures of metaphylaxis.

  • Drug therapy for xanthine stone formation is not available.