The following are the major conditions or complications that may be contributed to by latent metabolic (metabolic-related) acidosis:
Certain conditions originating in the perinatal period (P00-P96).
- Growth impairment of premature infants
Blood, hematopoietic organs – immune system (D50-D90).
- Loss of activity of NK cells (natural killer cell; natural killer cells).
- Inhibition of lymphocyte proliferation (infection defense).
Endocrine, nutritional and metabolic diseases (E00-E90).
- Diabetes mellitus type 2
- Wg. insulin resistance ↑
- Net endogenous acid production (NEAP), potential renal acid load (PRAL), and animal protein-to-potassium ratio (A:P) are positively associated with diabetes mellitus type 2
- Insulin resistance ↑
- Increase in extracellular potassium (hyperkalemia).
Factors affecting health status leading to health care utilization (Z00-Z99).
- Stress-in children, higher secretion of the stress hormone cortisol and the specific cellular cortisol remodeling products (eg, 6-beta-hydroxycortisol) was measured in the presence of increased renal acid excretion (net acid excretion, NAE)
Cardiovascular System (I00-I99).
- Hypertension risk ↑ – due to a slight shift in acid-base metabolism in childhood toward a higher acid load (acidification), regardless of salt intake.
Musculoskeletal system and connective tissue (M00-M99).
- Arthralgia (joint pain)
- Myalgia (muscle pain)
- Osteopenia (reduction in bone density; precursor to osteoporosis).
- Osteoporosis
Symptoms and abnormal clinical and laboratory parameters, not elsewhere classified (R00-R99).
- Poor performance
Complex disorders of acid-base metabolism are more common in early childhood than in other age groups. According to one study, even mild acidosis from food leads to impaired growth.
Other consequences
- Decrease in enzyme activities
- Diffusion disorders and thus reduced supply of tissues with nutrients and vital substances (macro- and micronutrients).
- Osmotic change (swelling and deformation) of cells.
- Deterioration of oxygen utilization and thus deterioration of organ functions (heart, kidneys, etc.)
- Decrease in vascular muscle response to catecholamines.
