Membrane Proliferative Glomerulonephritis | Forms Glomerulonephritis

Membrane Proliferative Glomerulonephritis

Membrane proliferative glomerulonephritis is also rather rare and unknown cause. It is often found in connection with hepatitis or malignant lymph node degeneration. At the beginning, a nephrotic syndrome with progressive symptoms up to renal insufficiency is often impressive. Currently, there is no effective therapy available. After 5 years, about 50% of those affected must undergo a machine blood purification procedure (dialysis).

Necrotizing intra-/extracapillary proliferative glomerulonephritis

In necrotizing intra-/extracapillary proliferative glomerulonephritis, the focus is on the rapidly progressive course over a few weeks and months. The symptoms include: This form can occur as a severe course of glomerulonephritis with immune complex formation (e.g. post-streptococci GN) or in the variant with antibody formation against the basement membrane. However, it can also occur without immune complex deposition.

Characteristic is a pathological cell death (necrosis). Crescent-shaped proliferations are also found in the fine tissue examination. Linear deposits of IgG-type antibodies along the basement membrane are found in histological preparations of the form with antibody formation against this basement membrane (e.g. Goodpasture’s syndrome).

The success of the therapy depends on the start of treatment. Immunosuppression and corticosteroid administration are in the foreground, supplemented by a mechanical exchange of blood plasma (plasmapheresis). If the therapy is initiated quickly and the creatinine level is below 6 mg/dl, the prognosis is favorable.

In most cases, however, a partial loss of function remains. Above a creatinine value of 6 mg/dl, the prognosis is worse and often ends in dialysis. <– Back to the main topic glomerulonephritis

• Signs of inflammation and antibody detection, if applicable
• Creatine increase
• High blood pressure
• Reduced to missing urine excretion (oligo-anuria)
• Edema (especially pulmonary edema in pulmonary overhydration)
• In the sonographic image usually normal sized kidneys