Methoxsalen

Products

Methoxsalen was commercially available as a solution for extracorporeal use and had been approved since 2008 (Uvadex, Meladinine). Both products are now off the market. In Germany, some drugs are still available. see also under Methoxsalen cream.

Structure and properties

Methoxsalen (C₁₂H₈O₄, M_r = 216.2 g/mol) is 8-methoxypsoralen, cf. psoralen.

Effects

Methoxsalen (ATC D05BA02) is photosensitizing.

Indications

• Psoriasis vulgaris
• Mycosis fungoides, other forms of cutaneous T-cell lymphoma.
• Vitiligo

Dosage

According to the professional information. Methoxsalen is used in combination with UVA irradiation (PUVA therapy).