The diagnosis of odontogenic tumor is usually made on the basis of the patient’s history and clinical examination as well as imaging techniques alone.
To confirm the tentative diagnosis when there is uncertainty in the diagnosis or an odontogenic tumor is difficult to treat – 2nd order laboratory parameters.
Histologic features of odontogenic tumors.
- Ameloblastoma, classic
- Proliferating epithelial associations with palisaded array of highly cylindrical cells
- Embedded in connective tissue stroma
- Histological variants:
- Solid (plexiform type)
- Cystic/multicystic (follicular type)
- Et al.
- Ameloblastic fibroma
- Proliferating epithelial strands and islands.
- Ectomesenchymal component resembling dental papilla or primitive pulp tissue
- Adenomatoid odontogenic tumor (AOT).
- Odontogenic epithelium
- Duct-like structures
- Cysts, if any
- If necessary calcifications
- Fibromyxoma
- Dental papilla, dental follicle as well as periodontal tissue as tissue of origin under discussion
- Round and angular cells in mucoid stroma.
- Calcifying odontogenic cyst
- Cyst bellows with small cell, multilayered odontogenic epithelium.
- Basal cell layer reminiscent of ameloblasts.
- In the epithelium, necrotic cells with absent nuclear staining (“ghost cells”) and patchy calcification
- Calcifying epithelial odontogenic tumor (KEOT).
- Epithelial neoplasia
- Intraepithelial amyloid-like calcifying deposits.
- Odontoma
- Connective tissue-like capsule
- Tooth-forming tissues mixed or rudimentary smallest tooth formations.
