Penile Cancer: Or something else? Differential Diagnosis

Skin and subcutaneous (L00-L99).

Fixed drug exanthema (gets its name because the exanthema (rash) does not completely disappear after discontinuation of the “triggering” drug)
Furuncle – purulent inflammation of hair follicles or sebaceous glands.
Infected epidermal cyst – cysts originating from hair follicles, several millimeters to two centimeters in size, prallelastic, skin-colored, which can grow slowly and become infected
Contact dermatitis ( allergic/irritant) – inflammatory reaction of the skin triggered by direct contact of the skin with allergens/irritants.
Lichen sclerosus (LS) (et atrophicus) (synonyms: lichen albus; lichen atrophicus; lichen sclerosus; lichen sclerosus et atrophicans; lichen sclerosus et atrophicus; morphoeid scleroderma; white spot disease; white spot diseas) – rare, chronic disease of the connective tissue, which is probably one of the autoimmune diseases.
Lichen ruber planus (nodular lichen).
Psoriasis (psoriasis) – penile shaft (36%), scrotum (scrotum; 33%), glans penis (glans; 29%).
Scabies (scabies) – penis (dash-shaped, partly also scratched up nodules, “penile papules”).

Infectious and parasitic diseases (A00-B99).

Gonorrhea (gonorrhea)
Granuloma inguinale (granuloma venereum; donovanosis) – tropical infectious disease.
Genital herpes – chronic, lifelong persistent viral disease, which in most cases arises from a primary infection with herpes simplex virus (HSV) type 2, sometimes by herpes simplex virus (HSV) type 1 (in about 30% of cases).
Herpes zoster (shingles)
HPV infections – e.g. Condylomata accuminata (synonyms: genital warts, wet warts, genital warts).
Lymphogranuloma venereum – often sexually transmitted infectious disease caused by Chlamydia trachomatis.
Scabies (scabies)
Syphilis (lues; venereal disease)
Tuberculosis (consumption) of the urinary tract.
Ulcus molle (soft chancre) – sexually transmitted disease caused by Haemophilus ducreyii.

Musculoskeletal system and connective tissue (M00-M99).

Behçet’s disease (synonym: Adamantiades-Behçet’s disease; Behçet’s disease; Behçet’s aphthae) – multisystem disease of the rheumatic type associated with recurrent, chronic vasculitis (vascular inflammation) of the small and large arteries and mucosal inflammation; The triad (the occurrence of three symptoms) of aphthae (painful, erosive mucosal lesions) in the mouth and aphthous genital ulcers (ulcers in the genital region), as well as uveitis (inflammation of the middle eye skin, which consists of the choroid (choroid), the corpus ciliary (corpus ciliare) and the iris) is stated as typical for the disease; a defect in cellular immunity is suspected

Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99).

Balanitis (acorn inflammation), mycotic (“fungal”) or bacterial.
Balanitis circinata – in the setting of Reiter’s disease (synonyms: Reiter’s syndrome; Reiter’s disease; arthritis dysenterica; polyarthritis enterica; postenteritic arthritis; posturethritic arthritis; undifferentiated oligoarthritis; urethro-oculo-synovial syndrome; Fiessinger-Leroy syndrome; Engl. Sexually acquired reactive arthritis (SARA)) occurring balanitis (acorn inflammation); Reiter’s triad: acute arthritis (joint inflammation), conjunctivitis (conjunctivitis), and urethritis (urethritis).
Balanitis plasmacellularis (Zoon’s disease) – reddish-brown, sharply demarcated glans redness, rather asymptomatic.
Balanitis xerotica et obliterans – inflammation of the glans associated with atrophy and sclerosis of the urethra.

Injuries, poisoning and other consequences of external causes (S00-T98).