Phosphatidyl Serine: Definition, Synthesis, Absorption, Transport and Distribution

Phosphatidyl serine (PS) is a naturally occurring phospholipid whose phosphoric acid residue is esterified with the amino acid serine.

Metabolism

PS, like phosphatidylcholine, can be synthesized endogenously in sufficient amounts. However, if there is a deficit of the amino acid methionine, vitamin B9 (folic acid), vitamin B12 (cobalamin), or essential fatty acids, sufficient phosphatidylserine cannot be formed by the body. Like lecithin, phospholipid forms the basic structure of cell membranes and is thus essential for the mobility and functionality of all body cells.

Phosphatidylserine is extremely important for the brain. There it is found in particularly high concentrations in the membranes of nerve cells.