Pulmonary Hypertension: Or something else? Differential Diagnosis

Respiratory System (J00-J99)

  • Bronchial asthma
  • Chronic obstructive pulmonary disease (COPD)
  • Interstitial lung disease
  • Pulmonary emphysemacondition in which there is increased air in the lungs. However, the gas exchange area is decreased. The reason for this is a destruction of the parenchyma (lung tissue).
  • Pulmonary fibrosisconnective tissue remodeling of the lungs, which leads to the destruction of the lung structure.

Certain conditions originating in the perinatal period (P00-P96).

  • Persistent pulmonary arterial hypertension of the newborn.

Blood, hematopoietic organs – immune system (D50-D90).

  • Sarcoidosis (synonyms: Boeck’s disease; Schaumann-Besnier’s disease) – systemic disease of connective tissue with granuloma formation (skin, lungs, and lymph nodes).
  • Sickle cell anemia (med.: Drepanocytosis; also sickle cell anemia, sickle cell anemia) – genetic disease with autosomal recessive inheritance, which affects the erythrocytes (red blood cells); it belongs to the group of hemoglobinopathies (disorders of hemoglobin; formation of an irregular hemoglobin, the so-called sickle cell hemoglobin, HbS).

Endocrine, nutritional, and metabolic diseases (E00-E90).

  • Glycogen storage diseases, unspecified.
  • Gaucher disease – genetic disorder with autosomal recessive inheritance; lipid storage disease due to the defect of the enzyme beta-glucocerebrosidase, resulting in the storage of cerebrosides mainly in the spleen and medullary bones.
  • Thyroid disease, unspecified

Cardiovascular system (I00-I99)

  • Left heart disease, unspecified
  • Pulmonary embolism-partial (partial) or complete obstruction of a pulmonary artery
  • Chronic thromboembolism – chronic occlusion of pulmonary vessels by thrombi (blood clots).
  • Familial pulmonary arterial hypertension
  • Idiopathic pulmonary arterial hypertension – form of the disease whose cause is unknown.
  • Mitral/aortic valve defect, unspecified.
  • Pulmonary veno-occlusive disease (PVOD) and/or pulmonary capillary hemangiomatosis (PCH).

Infectious and parasitic diseases (A00-B99).

  • Schistosomiasis – worm disease (tropical infectious disease) caused by trematodes (sucking worms) of the genus Schistosoma (couple flukes).
  • HIV infection/AIDS

Musculoskeletal system and connective tissue (M00-M99).

Liver, gallbladder, and bile ducts-pancreas (pancreas) (K70-K77; K80-K87).

Neoplasms – tumor diseases (C00-D48).

  • Bronchial carcinoma (lung cancer)
  • Histiocytosis/Langerhans cell histiocytosis (abbreviation: LCH; formerly: histiocytosis X; Engl. histiocytosis X, langerhans-cell histiocytosis) – systemic disease with proliferation of Langerhans cells in various tissues (skeleton 80% of cases; skin 35%, pituitary gland (pituitary gland) 25%, lung and liver 15-20%); in rare cases, neurodegenerative signs may also occur; in 5-50 % of cases, diabetes insipidus (hormone deficiency-related disturbance in hydrogen metabolism, leading to extremely high urine excretion) occurs when the pituitary gland is affected; the disease occurs disseminated (“distributed over the whole body or certain regions of the body”) frequently in children between 1-15 years of age, less frequently in adults, here predominantly with an isolated pulmonary affection (lung affection); prevalence (disease frequency) approx. 1-2 per 100,000 inhabitants
  • Lymphangiomatosis – rare disease state characterized by diffuse proliferation of lymphatic vessels. This can affect internal organs, bones, soft tissues, and the skin
  • Myeloproliferative neoplasms (MPNs): chronic myeloid leukemia (CML), myelofibrosis, polycythaemia vera (PV), and essential thrombocythaemia (ET).
  • Pulmonary capillary hemangiomatosis (PCH) – occurrence of numerous benign vascular tumors.

Psyche – Nervous System (F00-F99; G00-G99).

Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99).

Injuries, poisoning, and other sequelae of external causes (S00-T98).

  • Chronic altitude sickness

Further

  • Compression of pulmonary vessels – by tumors, foreign bodies, parasites, etc.
  • Condition following splenectomy (removal of spleen).

Medication

  • Amphetamines
  • Appetite suppressants, unspecified
  • Drugs, unspecified