Tazobaktam belongs to the group of beta-lactamase inhibitors (also called beta-lactamase inhibitors). These drugs are usually given in a fixed combination, as this is the best way to make them work. Tazobactam is given in combination with piperacillin and is available under the trade name Tazobac®. Other combinations would be amoxicillin+clavulanic acid, ampicillin+Sulbactam, sultamicillin+Sulbactam.
Effect
All beta-lactamase inhibitors inhibit part of the bacterial enzyme beta-lactamase. This enzyme prevents the bacteria from inhibiting the beta-lactam ring of beta-lactam antibiotics (penicillin, cephalosporin, carbapenem). Thus, the combination partners of the beta-lactamase inhibitors can work better.
Special feature
The preparations are usually given in combination with each other, which makes them more effective against bacteria (sulbactam+ampicillin, tazobactam+piperacillin, clavulanic acid+amoxicillin).
Side effects
In the combination of tazobactam and piperacillin, diarrhea, nausea, vomiting and rashes are very common. Less frequently, infections due to resistant germs, reduced leukocyte count in the blood (leocopenia), reduced platelet count (thrombocytopenia), hypersensitivity reactions, headache, low blood pressure (hypotension), sleep disorders (insomnia) may occur, Inflammation of the veins (phlebitis), constipation, indigestion, inflammation of the mucous membrane of the mouth (stomatitis), an increase in liver enzymes, a yellowing of the skin (icterus), itching and rashes, red coloring of the skin (erythema), an increase in creatinine and fever.
Fields of application
Tazobactam Among the treatable gram-negative germs, anaerobically growing bacteria can also be treated with tazobactam (Tazobac) (Bacteroides fragilis Chlamydia spp. Fusobacterium spp. Mycoplasma spp. )
Especially infections of the gastrointestinal tract (secondary peritonitis, cholangitis, cholecystitis, diverticulitis, abscess in the abdominal cavity) and respiratory diseases (pneumonia acquired in hospital or outpatient) are treated with tazobactam. Tazobac® is also used to treat soft-tissue infections of the skin (e.g. pressure sores or diabetic foot syndrome).
- Enterococcus faecalis
- Staphylococcus aureus
- Staphylococcus epidermidis
- Staphylococcus haemolyticus
- Staphylococcus hominis
- Staphylococcus agalacticae
- Staphylococcus pneumoniae
- Staphylococcus pyogenes.
- Eikenella corrodens
- Acinetobacter baumanii
- Escherichia coli
- Haemophilus influenzae
- Klebsiella Pneumoniae
- M.
Catarrhalis
- M. morganii
- P. Mirabillis
- P. Vulgaris
- Pseudomonas aeroginosa