Products
Oxprenolol is no longer available in many countries. Trasicor, slow-trasitensine (+ chlortalidone), and slow-trasicor are off label.
Structure and properties
Oxprenolol (C15H23NO3, Mr = 265.3 g/mol) is present in drugs as oxprenolol hydrochloride, a racemate and a white crystalline powder that is very soluble in water.
Effects
Oxprenolol (ATC C07AA02) has antihypertensive and antiarrhythmic properties, among others. Oxprenolol is a nonselective lipophilic beta blocker with sympatholytic activity and mild to moderate intrinsic sympathomimetic activity (ISA). Oxprenolol has a short half-life of one to two hours and therefore has been administered in sustained-release tablet form.
Indications
- Hypertension
- Angina pectoris
- Cardiac arrhythmias
- Functional, sympathicotonic cardiovascular disorders
Dosage
According to the professional information. The tablets were taken one to three times a day.
Contraindications
Full details of precautions and interactions can be found in the drug label.
Adverse effects
The most common possible adverse effects include dry mouth, constipation, respiratory disorders, bronchospasm, low blood pressure, heart failure, libido and potency disorders, fatigue, dizziness, headache, mental depression, sleep disturbances, nightmares, peripheral circulation disorders, and nausea.
