Products Retigabine was approved in many countries as film-coated tablets since 2011 (Trobalt). In the United States, it is referred to as ezogabine. It was discontinued in 2017. Structure Retigabine (C16H18FN3O2, Mr = 303.3 g/mol) is a carbamate that was developed starting from the analgesic flupirtine. The free primary amino group is -glucuronidated (see below). … Retigabine (Ezogabine)
Effects Reverse transcriptase inhibitors (ATC J05AF) have antiviral properties against HIV. The effects are due to inhibition of the viral enzyme reverse transcriptase, which transcribes viral RNA into DNA and is important for viral replication. Structure and properties Within the drug group, two distinct classes are distinguished. The so-called nucleoside reverse transcriptase inhibitors, abbreviated NRTIs, … Reverse Transcriptase Inhibitors (HIV)
Products Dexmethylphenidate is commercially available in the form of capsules with a modified release of active ingredient (Focalin XR). It was approved in many countries in 2009. Since it does not contain L-threo-methylphenidate, the strengths are correspondingly half less (5 mg, 10 mg, 15 mg, 20 mg) than Ritalin LA (10 mg, 20 mg, 30 … Dexmethylphenidate
Products The fixed combination Deanxit with the two active ingredients melitracene and flupentixol is commercially available in many countries in the form of film-coated tablets. The drug has been approved since 1973, initially as dragées. The marketing authorization holder is the Danish company Lundbeck. Structure and properties The active ingredients are present in the drug … Melitracene and Flupentixol
Products Memantine is commercially available as film-coated tablets, meltable tablets, and oral solution (Axura, Ebixa). It has been approved in many countries since 2003. Generic versions were registered in 2014. Structure and properties Memantine (C12H21N, Mr = 179.3 g/mol) is present in drugs as memantine hydrochloride, a white powder that is insoluble in water. Memantine … Memantine
Products Lycopene is not approved as a drug in many countries, but is marketed as a dietary supplement and food coloring (e.g., Alpinamed). In the English-speaking world, it is referred to as. Structure and properties Lycopene (C40H56, Mr = 536.9 g/mol) is a naturally occurring hydrophobic carotenoid found in tomatoes that gives them their red … Lycopene
Products The inhaled human insulin Exubera (Pfizer, powder inhalation) is no longer commercially available. It was withdrawn from the market in 2007 for commercial reasons. In 2014, a new product was approved in the United States; see Inhalable Insulin. Structure and properties Human insulin (C257H383N65O77S6, Mr = 5808 g/mol) is a polypeptide with the structure … Exubera
Products Somatropin is commercially available as an injectable from several manufacturers. Recombinant growth hormone has been available since the late 1980s. Biosimilars are approved in some countries. Structure and properties Somatropin is a recombinant polypeptide hormone with a molecular mass of 22 kDa, consisting of 191 amino acids. It corresponds to human growth hormone from … Somatropin
Products Cariprazine was approved in the United States in 2015 and in many countries and the EU in 2018 in capsule form (Reagila, some countries: Vraylar). Structure and properties Cariprazine (C21H32Cl2N4O, Mr = 427.4 g/mol) is a piperazine and dimethylurea derivative. It is present in the drug as cariprazine hydrochloride, a white powder. Active metabolites … Cariprazine
Products Carmustine is commercially available in many countries as a powder and solvent for the preparation of an infusion solution (BiCNU). An implant is also available in some countries (Gliadel). Structure and properties Carmustine (C5H9Cl2N3O2, Mr = 214.0 g/mol) belongs to the nitrosoureas. It exists as a yellowish, granular powder that is very sparingly soluble … Carmustine
Products Ofatumumab was approved in 2009 as a concentrate for the preparation of an infusion solution for leukemia treatment (Arzerra). In 2020, a solution for injection was approved in the United States for MS treatment (Kesimpta). Structure and properties Ofatumumab is a human IgG1 monoclonal antibody produced by biotechnological methods. It has a molecular mass … Ofatumumab
Products Anti-allergy medications are available in numerous dosage forms. These include tablets, capsules, solutions, suspensions, nasal sprays, eye drops, inhalation preparations, and injectables. Structure and properties Antiallergic drugs do not have a uniform chemical structure. However, several groups within the class can be identified (see below). Effects Antiallergic drugs have antiallergic, antiinflammatory, immunosuppressive, antihistamine, and … Antiallergics
