Products Cyproheptadine is no longer commercially available in many countries (formerly Periactin). In the United States, it is available in tablet, syrup, and powder forms, among others. Structure and properties Cyproheptadine (C21H21N, Mr = 287.4 g/mol) is a methylpiperidine derivative structurally related to pizotifen (Mosegor, off label). It is present in drugs as cyproheptadine hydrochloride, … Cyproheptadine
Products Ebastine is commercially available in the form of film-coated tablets (e.g., Ebastel). The drug is not registered in many countries. Structure and properties Ebastine (C32H39NO2, Mr = 469.7 g/mol) Effects Ebastine (ATC R06AX22) has antiallergic properties. It is not anticholinergic and barely crosses the blood–brain barrier. Indications For symptomatic treatment of seasonal and perennial … Ebastine
Products Cetirizine is commercially available as film-coated tablets, lozenges, and drops (Zyrtec, generic). It has been approved in many countries since 1989. Structure and properties Cetirizine (C21H25ClN2O3, Mr = 388.9 g/mol) is a racemate consisting of –levocetirizine and -dextrocetirizine. It is present in drugs as cetirizine dihydrochloride, a white powder that is readily soluble in … Cetirizine Effects and Side Effects
Products Terfenadine (Teldane tablets/suspension) is no longer on the market in many countries. Possible alternatives are the successor product fexofenadine (Telfast) or other 2nd generation antihistamines. Structure and properties Terfenadine (C32H41NO2, Mr = 471.7 g/mol) is a racemate. It exists as a white crystalline powder that is very sparingly soluble in water. Terfenadine is a … Terfenadine
Products Leukotriene antagonists are commercially available as film-coated tablets, granules, and chewable tablets. Structure and properties The active ingredients do not have a uniform chemical structure. Effects The leukotriene antagonists (ATC R03DC) have antiasthmatic, anti-inflammatory, bronchodilator, and antiallergic properties. They bind to the CysLT1 receptor, thereby inhibiting the effects of the cysteinyl leukotrienes LTC4, LTD4, … Leukotriene Antagonists
Products Levocetirizine is commercially available in the form of film-coated tablets and as drops (Xyzal, generic). It has been approved in many countries since 2001. Levocetirizine is the -enantiomer of cetirizine (Zyrtec, both UCB-Pharma SA). Levocetirizine tablets contain 5 mg of active ingredient; cetirizine tablets contain 10 mg (plus 5 mg of the -enantiomer). Unlike … Levocetirizine
Products Doxylamine is commercially available in many countries as a solution (Sanalepsi N). It is also contained in Vicks MediNait juice in combination with dextromethorphan, ephedrine, and acetaminophen. In 2020, hard capsules containing doxylamine and pyridoxine were approved in many countries for the treatment of nausea and vomiting in pregnancy (Cariban). Pharmacies also make a … Doxylamine
Symptoms The possible symptoms of a stuffy nose include difficult nasal breathing, swelling of the mucous membrane, a feeling of fullness, secretions, crusting, rhinitis, itching, and sneezing. The stuffy nose often occurs at night while lying down and also triggers insomnia, sore throat and headache. Causes A stuffy nose restricts the flow of air through … Blocked Nose
Products Montelukast is commercially available as film-coated tablets and as granules and chewable tablets for children (Singulair, generic). It has been approved in many countries since 1998. Structure and properties Montelukast (C35H36ClNO3S, Mr = 586.18 g/mol) is a chloroquinoline derivative. It is present in drugs as montelukast sodium, a white crystalline powder that is readily … Montelukast
Definition Nasonex® is a drug that is often used as a nasal spray to treat allergic or inflammatory diseases of the nasopharynx. The active ingredient is called mometasone and belongs to the group of highly effective glucocorticoids. Mometasone is also used in ointments and creams and is thus used locally against allergic or inflammatory skin … Nasonex®
Application areas Nasonex has two main applications. The most important one is allergic rhinitis, which can be seasonal, probably better known as hay fever, or year-round. As the name suggests, it is an allergic reaction in certain months to pollen or grasses, or without a time connection, e.g. to cat hairs or dust mites. Nasonex … Application areas | Nasonex®
Products Desloratadine is commercially available as 5 mg film-coated tablets and as a solution (Aerius, generics). It has been approved in many countries since 2001. The syrup was replaced in 2011 by a solution that is sugar- and dye-free. The concentration remains identical (0.5 mg/ml). The fixed combination with pseudoephedrine is not yet available in … Desloratadine
