Effects ADH analogs (ATC H01BA) are derivatives of the antidiuretic hormone ADH (= vasopressin), which has antidiuretic and vasoconstrictor properties. The vasopressin analogs are modified to be predominantly antidiuretic or predominantly vasoconstrictor. Indications Diabetes insipidus Enuresis nocturna (bedwetting) Polyuria, polydipsia after hypophysectomy. Acute esophageal variceal bleeding (Terlipressin). Agents Desmopressin Terlipressin
Products Terlipressin is commercially available as an injectable (glypressin, haemopressin). It has been approved in many countries since 1982. Structure and properties Terlipressin (triglycyl lysine vasopressin) is a synthetic analog of vasopressin, the antidiuretic hormone (ADH). It differs from ADH in four amino acids: Terlipressin: Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly ADH: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly. Effects Terlipressin (ATC H01BA04) has vasoconstrictor properties, … Terlipressin
Products Desmopressin is commercially available as a solution for injection, in the form of nasal drops, as a nasal spray, tablets, and sublingual tablets (e.g., Minirin, Nocutil, other drugs). It has been approved in many countries since 1973. Structure and properties Desmopressin (C48H68N14O14S2, Mr = 1129.3 g/mol) is present in the drugs as desmopressin acetate, … Desmopressin
Products and production Morphine drops are an aqueous dropping solution of morphine hydrochloride, usually in concentration 1% or 2%, maximum 4%. The concentration refers to the salt; the effective amount of morphine base is less. The drug is subject to strict control as an anesthetic and is available only on prescription. The morphine drops of … Morphine Drops
Products Diazoxide is commercially available in capsule form (Proglicem). It has been approved in many countries since 1978. Structure and properties Diazoxide (C8H7ClN2O2S, Mr = 230.7 g/mol) exists as a white powder that is practically insoluble in water. It is a benzothiadiazine derivative and structurally related to the thiazides, but is not diuretic. Effects Diazoxide … Diazoxide
