Products Azacitidine is commercially available as a lyophilizate for the preparation of a suspension for injection (Vidaza, generic). It has been approved in many countries since 2006. Structure and properties Azacitidine (C8H12N4O5, Mr = 244.2 g/mol) is a derivative of the nucleoside cytidine found in nucleic acids. It belongs to the pyrimidine nucleoside analogues. Azacitidine … Azacitidine
Products Most statins are commercially available in the form of film-coated tablets, and some are also available as capsules. The first active ingredient to be marketed was lovastatin from Merck in the United States in 1987. In many countries, simvastatin (Zocor) and, shortly thereafter, pravastatin (Selipran) were the first agents to be approved in 1990. … Statins
Products Acai berries (pronounced ass-a-i) are commercially available in many countries as juice, powder, in the form of capsules and cosmetics, among other products. They belong to the so-called superfoods. Stem plant The parent plant of the berries is the palm Mart. (Arecaceae), which is native to South America and grows in the regularly flooded … Acai Berries
Products Cortisone tablets are medicinal products which are intended for ingestion and contain active substances from the group of glucocorticoids. The tablets, water-soluble tablets and sustained-release tablets are usually monopreparations, which are often divisible. Glucocorticoids were first used medicinally in the late 1940s. Structure and properties The glucocorticoids contained in the drugs are derived from … Cortisone Tablets Effects and Side Effects
Products Castellani solution is not commercially available as a registered finished drug in many countries and must be prepared in a pharmacy as an extemporaneous preparation. Retailers can also order it from specialized suppliers. The drug is named after Aldo Castellani (1877-1971), a well-known Italian tropical physician who developed it in the 1920s. Ingredients Traditional … Castellani Solution
Products Sunitinib is commercially available in capsule form (Sutent). It has been approved in many countries since 2006. Structure and properties Sunitinib (C22H27FN4O2, Mr = 398.5 g/mol) is present in the drug as sunitinibmalate, a yellow to orange powder that is soluble in water. It is an indolin-2-one and pyrrole derivative. It has an active … Sunitinib
Products Abemaciclib was approved in the form of film-coated tablets in the United States in 2017, in the EU in 2018, and in many countries in 2019 (Verzenios). Structure and properties Abemaciclib (C27H32F2N8, Mr = 506.6 g/mol) exists as a white to yellow powder. Effects Abemaciclib (ATC L01XE50) has antitumor and antiproliferative properties. The effects … Abemaciclib
Products Carfilzomib was approved in many countries in 2015 as a powder for the preparation of an infusion solution (Kyprolis). Structure and properties Carfilzomib (C40H57N5O7, Mr = 719.9 g/mol) exists as a crystalline substance that is practically insoluble in water. It is a peptide derivative, a tetrapeptide epoxyketone. Epoxyketones are derivatives of epoxomicin, a natural … Carfilzomib
Products Crizotinib has been approved in many countries since 2012 in capsule form (Xalkori). Structure and properties Crizotinib (C21H22Cl2FN5O, Mr = 450.3 g/mol) is an aminopyridine. It exists as a white to yellowish powder that is soluble in acidic solution to 10 mg/mL. Effects Crizotinib (ATC L01XE16) has antitumor and antiproliferative properties. The effects are … Crizotinib
Products Trametinib was approved in the form of film-coated tablets in the United States in 2013, in the EU in 2014, and in many countries in 2016 (Mekinist). Structure and properties Trametinib (C26H23FIN5O4, Mr = 615.4 g/mol) is a pyridine and a pyrimidine derivative. It is present in the drug product as trametinib dimethyl sulfoxide, … Trametinib
Products Trastuzumab is commercially available as a lyophilizate for preparation of an infusion concentrate (Herceptin, biosimilars). It has been approved in many countries since 1999 (US: 1998, EU: 2000). In 2016, an additional solution for subcutaneous injection for breast cancer therapy was released in many countries (Herceptin subcutaneous). It was available earlier in other countries. … Trastuzumab
Products Dasatinib is commercially available in the form of film-coated tablets (Sprycel). It has been approved in many countries since 2007. Generic versions were registered in 2020. Structure and properties Dasatinib (C22H26ClN7O2S, Mr = 488.0 g/mol) exists as a white powder that is insoluble in water. It is an aminopyrimidine derivative. Effects Dasatinib (ATC L01XE06) … Dasatinib
