Products Pimozide is no longer commercially available as a finished drug in many countries. It is still available in some countries (Orap tablets). Structure and properties Pimozide (C28H29F2N3O, Mr = 461.5 g/mol) belongs to the diphenylbutylpiperidines. It exists as a white powder that is practically insoluble in water. Effects Pimozide (ATC N05AG02) is antipsychotic. The … Pimozide
Products Pipamperone is commercially available in tablet form (dipiperone). It has been approved in many countries since 1964. Structure and properties Pipamperone (C21H30FN3O2, Mr = 375.5 g/mol) is present in drugs as pipamperondihydrochloride. It is structurally closely related to haloperidol, which also belongs to the butyrphenones. Butyrphenones, like numerous other active ingredients, originated in the … Pipamperon
Products Sertindole is commercially available in the form of film-coated tablets (Serdolect). It has been approved in many countries since 1997. Structure and properties Sertindole (C24H26ClFN4O, Mr = 440.9 g/mol) was developed as the first neuroleptic with a phenylindole structure. Effects Sertindole (ATC N05AE03) has antipsychotic properties. The effects are due to antagonism at dopamine … Sertindol
Products Brexpiprazole was approved in the United States in 2015 and in the EU and many countries in 2018 in film-coated tablet form (Rexulti). Structure and properties Brexpiprazole (C25H27N3O2S, Mr = 433.6 g/mol) is structurally closely related to aripiprazole (Abilify, generics). Effects Brexpiprazole (ATC N05AX16) has antipsychotic properties. The effects are due to partial agonism … Brexpiprazole
Products Aripiprazole is commercially available in tablet, meltable tablet, syrup, solution for injection, and sustained-release injection suspension forms (Abilify, Abilify Maintena, generics). It has been approved in many countries since 2004 and in the United States since 2002. Generics entered the market in 2015. Also used is the prodrug aripiprazollauroxil (Aristada). Structure and properties Aripiprazole … Aripiprazole
Products Aripiprazollauroxil was newly approved in the United States in 2015 as a suspension for injection (Aristada). It has not yet been registered in many countries. Structure and properties Aripiprazollauroxil (C36H51Cl2N3O4, Mr = 660.7 g/mol) is the ester of -hydroxymethyl aripiprazole and lauric acid. Aripiprazollauroxil is a prodrug of aripiprazole (Abilify, generic). Unlike oral aripiprazole, … Aripiprazollauroxil
Products Levomepromazine is commercially available as film-coated tablets and oral solution (Nozinan). It has been approved in many countries since 1958. Structure and properties Levomepromazine (C19H24N2OS, Mr = 328.5 g/mol) is present in the drugs as levomepromazine hydrochloride or levomepromazine maleate. These are faint yellowish crystalline powders. Levomepromazine maleate is sparingly soluble in water and … Levomepromazine
Products Lumateperone was approved in the United States in 2019 in capsule form (Caplyta). Structure and properties Lumateperone (C24H28FN3O, Mr = 393.5 g/mol) is present in the drug as lumate perontosylate. Like haloperidol (Haldol), for example, it belongs to the butyrophenone group. Effects Lumateperone has antipsychotic and antidepressant properties. Effects are attributed to antagonism at … Lumateperon
Products Lurasidone is commercially available in the form of film-coated tablets (Latuda). It has been approved in many countries since 2013. In the United States, it was registered as early as 2010. Structure and properties Lurasidone (C28H36N4O2S, Mr = 492.7 g/mol) belongs to the benzoisothiazoles. It exists as a white powder that is sparingly soluble … Lurasidon
