Products Insulin glargine is commercially available as an injectable (Lantus). It has been approved in many countries since 2002. The biosimilar Abasaglar (LY2963016) was approved in the EU in 2014 and in many countries in 2015. The drugs must be stored between 2 to 8°C in a refrigerator. In 2015, Toujeo was additionally approved in … Insulin Glargine
Products Insulin lispro is commercially available as an injectable (Humalog). It has been approved in many countries since 1995. Biosimilars are available in some countries. In 2021, Lyumjev was approved in many countries, a new formulation that is characterized by an (even) faster onset of action and a slightly shorter duration of action. Structure and … Insulin Lispro
Products Insulins are primarily commercially available in the form of clear injection solutions and turbid injection suspensions (vials, cartridges for pens, ready-to-use pens). In some countries, inhalation preparations are also available. However, these are an exception. Insulins should be stored in a refrigerator at 2 to 8°C (see under Refrigerated Storage). They must not be … Insulins
Products Adalimumab is commercially available as a solution for injection (Humira). It was approved in the United States in 2002 and in many countries and the EU in 2003. Biosimilars are available in many countries. Structure and properties Adalimumab is a human IgG1 monoclonal antibody against TNF-alpha. It is composed of 1330 amino acids and … Adalimumab Effects and Side Effects
Products The first therapeutic monoclonal antibody was approved in 1986. Muromonab-CD3 (Orthoclone OKT3) binds to the CD3 receptor on T cells and has been used in transplantation medicine. Numerous drugs containing antibodies are now available. A selection of active substances can be found at the end of this article. These are expensive drugs. For example, … Monoclonal Antibodies
Products Therapeutic proteins are usually administered in the form of injection and infusion preparations and must be stored in a refrigerator. The first recombinant protein to be approved was human insulin in 1982. Some proteins, for example, are also available in tablet, capsule, and powder form and can be stored at room temperature, such as … Therapeutic Proteins
Definition In a medication analysis, the medications that a patient is using are reviewed by a healthcare professional for various aspects. The objectives of the analysis include the following: Optimization of therapy and use, improvement of health status. Avoidance of adverse effects and drug-drug interactions. Increasing adherence to therapy Discontinuation of unnecessary medication Recognizing risks … Medication Analysis
Products VEGF inhibitors are commercially available as injectables from various suppliers. The first agent in this group to be approved was pegaptanib (Macugen) in 2004, which is now off the market in many countries. Structure and properties The currently available VEGF inhibitors are therapeutic proteins (biologics). They are antibodies, antibody fragments, and fusion proteins. They … VEGF Inhibitors
Products Teriparatide is commercially available as a solution for injection in a prefilled injector (Forsteo, some countries also: Forteo). It was approved in the United States in 2002 and in the EU and many countries in 2003. The drug must be stored in a refrigerator and must not be frozen. Biosimilars are approved in many … Teriparatide
Products Bevacizumab is commercially available as a concentrate for the preparation of an infusion solution (Avastin). It was approved in many countries and in the United States in 2004 and in the EU in 2005. Biosimilars have been approved in some countries and also in many countries. Structure and properties Bevacizumab is a recombinant, humanized … Bevacizumab
Products Biosimilars are copycat preparations of biotechnology-derived drugs (biologics) that have strong similarities to the originator drugs but that are not exactly the same. The similarity relates to biological activity, structure, function, purity and safety, among other things. Biosimilars differ from generics of small molecule drugs in important ways. Biosimilars are usually marketed as injection … Biosimilars
Symptoms In osteoporosis, bones become weak, porous, and brittle and undergo structural changes. Even minor stresses can lead to a fracture, especially of the vertebrae, femoral neck, and wrists. Fractures pose a risk to the elderly and can lead to pain, hospitalization, surgery and disability. In the worst cases, they are even life-threatening. Other possible … Osteoporosis Causes and Treatment
