Definition Prescription drugs are a group of drugs that may be obtained from a pharmacy only with a doctor’s prescription. The prescription is usually issued during a consultation. Within this group, different dispensing categories exist in many countries. The presence of a doctor’s prescription is often a condition for the health insurance company to reimburse … Prescription Drugs
Products Sitaxentan had been on the market in the EU since 2006 in the form of film-coated tablets (Thelin 100 mg, Pfizer). It was withdrawn from the market in 2010 because of liver-toxic side effects. Structure and properties Sitaxentan (C18H15ClN2O6S2, Mr = 454.9 g/mol) is an oxazole, thiophene, benzodioxole, and sulfonamide derivative. It is present … Sitaxentan
Products Ambrisentan is commercially available in the form of film-coated tablets (Volibris). It has been approved in many countries since 2008. Generic versions were registered in 2020. Structure and properties Ambrisentan (C22H22N2O4, Mr = 378.4 g/mol) is a dimethylpyrimidine, diphenyl and propionic acid derivative and exists as a white crystalline powder that is practically insoluble … Ambrisentan
Products Endothelin receptor antagonists are commercially available in the form of film-coated and dispersible tablets. The first agent in this group to be approved was bosentan (Tracleer) in the United States in 2001 and in the EU and Switzerland in 2002. Effects Antivasoconstrictive Reduce pulmonary and systemic vascular resistance Higher blood flow volume without increasing … Endothelin Receptor Antagonists
Products Macitentan is commercially available in the form of film-coated tablets (Opsumit). It was approved in the United States in October 2013 and in many countries in 2014. Macitentan was launched as a successor to bosentan (Tracleer) as it loses patent protection. Structure and properties Macitentan (C19H20Br2N6O4S, Mr = 588.3 g/mol) is a brominated pyrimidine … Macitentan
Products Glibenclamide is commercially available in tablet form (Daonil, generics). It has been approved in many countries since 1970 and is also used in fixed combination with metformin (Glucovance). Structure and properties Glibenclamide (C23H28ClN3O5S, Mr = 494.0 g/mol) is a sulfonylurea. It exists as a white crystalline powder that is practically insoluble in water. Effects … Glibenclamide
Products Bosentan is commercially available in the form of tablets and dispersible tablets (Tracleer). It has been approved in many countries since 2002. Generic versions were registered in 2017. Structure and properties Bosentan (C27H29N5O6S, Mr = 551.6 g/mol) is present in drugs as bosentan monohydrate, a white to yellowish powder that is poorly soluble in … Bosentan
Symptoms Pulmonary arterial hypertension may initially be asymptomatic. It manifests as symptoms such as difficulty breathing that worsens with exertion, shortness of breath, fatigue, chest pain, brief loss of consciousness, cyanosis, and palpable heartbeats. Possible complications include cor pulmonale, blood clots, arrhythmias, and bleeding. Causes The condition is caused by an increase in pressure in … Pulmonary Arterial Hypertension
