Products Dopamine agonists are commercially available in the form of tablets, sustained-release tablets, transdermal patches, and injectables, among others. Structure and properties The first active ingredients, such as bromocriptine (Figure), were derived from ergot alkaloids. These are referred to as ergoline dopamine agonists. Later, agents with a nonergoline structure, such as pramipexole, were also developed. … Dopamine Agonists
Products Doxepin is commercially available in many countries in capsule form (Sinquan) and has been approved since 1968. Structure and properties Doxepin (C19H21NO, Mr = 279.4 g/mol) is present in drugs as doxepin hydrochloride, a white crystalline powder that is readily soluble in water. It is a dibenzoxepin derivative. Effects Doxepin (ATC N06AA12) has antidepressant, … Doxepin: Drug Effects, Side Effects, Dosage and Uses
Products Cyproheptadine is no longer commercially available in many countries (formerly Periactin). In the United States, it is available in tablet, syrup, and powder forms, among others. Structure and properties Cyproheptadine (C21H21N, Mr = 287.4 g/mol) is a methylpiperidine derivative structurally related to pizotifen (Mosegor, off label). It is present in drugs as cyproheptadine hydrochloride, … Cyproheptadine
Products Chlorpromazine was commercially available in various oral and parenteral dosage forms (e.g., Chlorazine, Thorazine, Largactil, Megaphene). It was first used in the 1950s as one of the first synthetic antipsychotics. Today, it is no longer a registered drug in many countries. In some countries, chlorpromazine is still on the market. Structure and properties Chlorpromazine … Chlorpromazine
Products Chlorprothixene is commercially available in the form of film-coated tablets (Truxal). It has been approved in many countries since 1960. Distribution of the so-called Truxal 5 mg tablets was discontinued in many countries in 2011 for economic reasons. Structure and properties Chlorprothixene (C18H18ClNS, Mr = 315.9 g/mol) belongs to the thioxanthenes. It is present … Chlorprothixene
Products Sufentanil is commercially available as a solution for injection (Sufenta, generic). It was developed in the 1970s and has been approved in many countries since 1994. Sublingual tablets for pain management are also available in some countries (Dzuveo, Zalviso). Structure and properties Sufentanil (C22H30N2O2S, Mr = 386.6 g/mol) is present in drugs as sufentanil … Sufentanil
Products Piritramid is available in Germany and Austria as a solution for injection (Dipidolor). No drugs containing the active ingredient are approved in many countries. Structure and properties Piritramide (C27H34N4O, Mr = 430.6 g/mol) is a diphenylpropylamine derivative developed at Janssen. It is structurally related to pethidine and fentanyl. Effects Piritramide (ATC N02AC03) has analgesic … Piritramid
Products The mixture of Sanalepsi solution (active ingredient: doxylamine 10 mg/ml) with valerian tincture is prepared in pharmacies as an in-house preparation. Because the sleeping pill and sedative Sanalepsi has been reclassified to dispensing category B (ex-list C) in 2019, dispensing in pharmacies must be done by the pharmacist. A consultation is required and dispensing … Sanalepsi with Valerian
Products Lasmiditan was approved in the United States in 2019 in film-coated tablet form (Reyvow). Structure and properties Lasmiditan (C19H18F3N3O2, Mr = 377.4 g/mol) is present in the drug as lasmiditanhemisuccinate, a white crystalline powder that is sparingly soluble in water. It is a piperidine and pyridine derivative and has no indole structure. Effects Lasmiditan … Lasmiditan
Products Guanfacine is commercially available in the form of sustained-release tablets (Intuniv). It has been approved in the United States since 2009, in the EU since 2015, and in many countries since 2017. Structure and properties Guanfacine (C9H9Cl2N3O, Mr = 246.1 g/mol) is a phenylacetyl guanidine derivative. It is present in drugs as guanfacine hydrochloride, … Guanfacin
Products Mianserin is commercially available in the form of film-coated tablets (generic). It was approved in many countries in 1981. The original Tolvon is no longer marketed. Structure and properties Mianserin (C18H20N2, Mr = 264.4 g/mol) is structurally and pharmacologically closely related to mirtazapine (Remeron, generics) and is present in the drug as mianserin hydrochloride, … Mianserin
Products Imipramine was commercially available in the form of dragées (Tofranil). It was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). It was approved in many countries in 1958 as the first active ingredient in the tricyclic antidepressant group. In … Imipramine: Drug Effects, Side Effects, Dosage and Uses