Products Interferons are sold exclusively as injectables, for example, in the form of prefilled syringes. They are stored in the refrigerator at 2 to 8°C. The body’s own cytokines were discovered in the 1950s. Structure and properties Interferons are proteins with a molecular weight between 15 to 21 kDa. They are now produced by biotechnological … Interferons
Chronic myeloid leukemia (CML) is a specific subtype of leukemia in which the white blood cells in the blood become diseased and have a harmful effect on the entire body. But how exactly can CML be diagnosed? And how can chronic myeloid leukemia be treated? What is chronic myeloid leukemia? Chronic myeloid leukemia involves white … Chronic Myeloid Leukemia: Causes, Symptoms & Treatment
Products Bosutinib is commercially available in the form of film-coated tablets (Bosulif). The drug was approved in many countries in 2014. Structure and properties Bosutinib (C26H29Cl2N5O3, Mr = 530.4 g/mol) is a quinoline and piperazine derivative. It is present in drugs as bosutinib monohydrate, a white to yellowish powder that is sparingly soluble in water. … Bosutinib
Synonyms in a broader sense Leukemia, white blood cancer, Philadelphia chromosome Definition CML (chronic myeloid lekemia) shows a chronic, i.e. rather slowly progressing course of the disease. This leads to the degeneration of a stem cell, which is a precursor of granulocytes in particular, i.e. cells that are important for the defence against mainly bacteria. … Chronic myeloid leukaemia (CML)
Chronic phase Most often, chronic myeloid leukaemia is discovered during the chronic phase. It corresponds to the initial stage of the disease and can last up to ten years. It often proceeds without symptoms, so that the initial diagnosis is often made rather coincidentally, e.g. in the context of a routine blood test by the … Chronic phase | Chronic myeloid leukaemia (CML)
Prognosis/life expectancy/healing chances According to the current state of science, chronic myeloid leukaemia cannot be cured with medication. In cases of advanced disease or lack of response to therapy, a bone marrow transplantation, which is curative in principle (i.e. promising to cure) but risky, can be considered. Therefore, it is not so easy to make … Prognosis/life expectancy/healing chances | Chronic myeloid leukaemia (CML)
Symptoms The possible signs and symptoms of chronic myeloid leukemia include: Fatigue Feeling sick Bleeding tendency Susceptibility to infectious diseases Lack of appetite, digestive problems, weight loss. Fever Night sweats Enlargement of the spleen and liver, pain. Disorders of hematopoiesis, bone marrow changes Pale skin In the bone marrow and blood, a strong proliferation and … Chronic Myeloid Leukemia
Imatinib is a tyrosine kinase inhibitor used primarily to treat chronic myeloid leukemia. It achieves good results in the treatment of chronic myeloid leukemia while being well tolerated. Its use in other malignancies is also possible. What is imatinib? Imatinib (trade name Gleevec) is a drug in the tyrosine kinase inhibitor group used to treat … Imatinib: Effects, Uses & Risks
Blood plasma plays a vital role as a liquid blood component in the human body. Therefore, blood plasma is also used in the context of medical or pharmaceutical applications. What is blood plasma? A blood plasma examination is used by doctors to further diagnose various diseases. Blood plasma is the non-cellular or liquid portion of … Blood Plasma: Function & Diseases
The heart is the “engine,” and the blood is the “fuel.” Around five to six liters of blood flows through the human body and accounts for about eight percent of body weight. Through blood vessels, the blood supplies the entire body with vital substances, without which the functionality of the organism can no longer be … Blood: Structure, Function & Diseases
Products Ponatinib is commercially available in film-coated tablet form (Iclusig). It was approved in the EU in 2013 and in many countries in 2014. Structure and properties Ponatinib (C29H27F3N6O, Mr = 532.6 g/mol) is present in the drug as ponatinib hydrochloride, a white to yellow powder whose water solubility decreases with increasing pH. It is … Ponatinib
Products Imatinib is commercially available in the form of film-coated tablets (Gleevec, Gleevec GIST, generic). It has been approved in many countries since 2001. Generics came on the market in 2016. They were not approved for the treatment of gastrointestinal stromal tumors (GIST) because this indication was still protected by a patent. In 2017, imatinib … Imatinib
