Products Oxcarbazepine is available in the form of film-coated tablets, sustained-release tablets, and as a suspension and commercially (Trileptal, Apydan extent). It has been approved in many countries since 1997. Structure and properties Oxcarbazepine (C15H12N2O2, Mr = 252.3 g/mol) exists as a white to faint orange crystalline powder and is practically insoluble in water. Oxcarbazepine … Oxcarbazepine
Products In many countries, drugs containing ergotamine are currently no longer on the market. The active ingredient was available in tablet form in combination with caffeine, among other products (Cafergot), but was withdrawn from the market in 2014. Products containing ergotamine were first launched in the 1920s (Gynergen). Structure and properties Ergotamine (C33H35N5O5, Mr = … Ergotamine
Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Products Most statins are commercially available in the form of film-coated tablets, and some are also available as capsules. The first active ingredient to be marketed was lovastatin from Merck in the United States in 1987. In many countries, simvastatin (Zocor) and, shortly thereafter, pravastatin (Selipran) were the first agents to be approved in 1990. … Statins
Products Suvorexant was approved in the United States in 2014 as the first agent in the orexin receptor antagonist group in the form of film-coated tablets (Belsomra). Structure and properties Suvorexant (C23H23ClN6O2, Mr = 450.9 g/mol) exists as a white powder that is insoluble in water. It is a benzoxazole, diazepane and triazole derivative. Effects … Suvorexant
Products Olaparib was approved in the United States and EU in 2014 and in many countries in 2015 in capsule form (Lynparza). Later, film-coated tablets were also registered. Structure and properties Olaparib (C24H23FN4O3, Mr = 434.5 g/mol) Effects Olaparib (ATC L01XX46) has antitumor and cytotoxic properties. The effects are due to inhibition of PARP (poly-(ADP-ribose) … Olaparib
Products Lipid-lowering agents are mainly sold as tablets and capsules as monopreparations and combination preparations. Some other dosage forms exist, such as granules and injectables. Statins have established themselves as the most important group at present. Structure and properties The chemical structure of lipid-lowering agents is inconsistent. However, within the class, groups with comparable structures … Lipid-Lowering Agents
Products Elvitegravir is commercially available as film-coated tablets in fixed combination with other antiretroviral agents and cobicistat (Stribild, successor: Genvoya). It has been approved in many countries since 2013. Stribild: elvitegravir, cobicistat, emtricitabine, and tenofovirdisoproxil. Genvoya: elvitegravir, cobicistat, emtricitabine and tenofoviralafenamide. Structure and properties Elvitegravir (C23H23ClFNO5, Mr = 447.9 g/mol) is a dihydroquinolone derivative. It … Elvitegravir
Products Prasugrel is commercially available in the form of film-coated tablets (Efient). It was approved in many countries, in the EU and in the US in 2009. Generic versions were registered in 2019. Structure and properties Prasugrel (C20H20FNO3S, Mr = 373.4 g/mol) belongs to the group of thienopyridines and exists as a hydrochloride as a … Prasugrel
Products Cobicistat is commercially available as a monopreparation (Tybost) and as a fixed combination with elvitegravir, emtricitabine, and tenofovirdisoproxil in the form of film-coated tablets (Stribild). It has been approved in many countries since 2013. Other combination products exist with darunavir (Rezolsta) and with atazanavir (Evotaz). Structure and properties Cobicistat (C40H53N7O5S2, Mr = 776.0 g/mol) … Cobicistat
Products Cobimetinib is commercially available in the form of film-coated tablets (Cotellic). It was approved in many countries in 2015. Structure and properties Cobimetinib (C21H21F3IN3O2, Mr = 531.3 g/mol) is present in the drug as cobimetinib hemifumarate, a white crystalline substance whose solubility is pH-dependent. Effects Cobimetinib (ATC L01XE38) has antitumor and antiproliferative properties. The … Cobimetinib
Products Itraconazole is commercially available in capsule form and as an oral solution (Sporanox, generic). It has been approved in many countries since 1992. Sporanox infusion concentrate is no longer available. Structure and properties Itraconazole (C35H38Cl2N8O4, Mr = 705.6 g/mol) exists as a white powder that is practically insoluble in water. It belongs to the … Itraconazole
