Products Lenvatinib was approved in many countries in 2015 in capsule form (Lenvima). In 2017, Kisplyx capsules were also approved. Structure and properties Lenvatinib (C21H19ClN4O4, Mr = 426.9 g/mol) is present in the drug as lenvatinib mesilate, a white to pale reddish-yellow powder that is sparingly soluble in water. It is a quinoline and carboxamide … Lenvatinib
Products Panobinostat was approved in many countries in 2015 in capsule form (Farydak). Structure and properties Panobinostat (C21H23N3O2, Mr = 349.4 g/mol) is present in the drug as panobinostat lactate, a white to slightly yellow or brownish powder that is sparingly soluble in water. It is an indole, a hydroxamic acid, and a propenamide derivative. … Panobinostat
Products Pantoprazole is commercially available in the form of enteric-coated tablets and has been approved in many countries since 1997 (Pantozol, generic). Less commonly used are the granules and the injectable. Structure and properties Pantoprazole (C16H15F2N3O4S, Mr = 383.37 g/mol) is a benzimidazole derivative and a racemate. In tablets, it is present as sodium salt … Pantoprazole
Products On the one hand, anabolic steroids are on the market as approved drugs, for example testosterone and other androgens. On the other hand, many agents are also produced and distributed illegally. Structure and properties Anabolic steroids structurally correspond to or are derived from androgens, the male sex hormones. The prototype of the group is … Anabolic Steroids: Synthetic Testosterone
Products Ciclosporin is commercially available as capsules, a drinkable solution, and an infusion concentrate (Sandimmune, Sandimmune Neoral, generics). It has been approved in many countries since 1995. Neoral is the microemulsion formulation that has more stable bioavailability than traditional Sandimmune. In 2016, ciclosporin eye drops were approved (see there). Structure and properties Ciclosporin (C62H111N11O12, Mr … Ciclosporin
Products Telaprevir is commercially available in the form of film-coated tablets (Incivo). It was approved in many countries in 2011. Structure and properties Telaprevir (C36H53N7O6, Mr = 679.8 g/mol) is a peptidomimetic and a ketoamide. It exists as a white crystalline powder that is sparingly soluble in water. Telaprevir is converted in the body to … Telaprevir
Products Nelfinavir was commercially available in the form of film-coated tablets (Viracept). It was approved in many countries in 1997 and withdrawn from the market in 2013 for commercial reasons. Structure and properties Nelfinavir (C32H45N3O4S, Mr = 567.8 g/mol) is present in the drug as nelfinavir mesilate, a white, amorphous powder that is sparingly soluble … Nelfinavir
Products Tinidazole (Fasigyn, 500 mg) is no longer available as a finished drug in many countries. It had been approved since 1973. Drugs containing the active ingredient can be imported from abroad or prepared in a pharmacy as an extemporaneous preparation. A substitute is metronidazole (Flagyl, generic). Structure and properties Tinidazole (C8H13N3O4S, Mr = 247.3 … Tinidazole
Products Bictegravir was approved in the United States and EU in 2018 and in many countries in 2019 in fixed combination with emtricitabine and tenofoviralafenamide in the form of film-coated tablets (Biktarvy). Structure and properties Bictegravir (C21H18F3N3O5, Mr = 449.4 g/mol) exists as a white to yellowish substance. Effects Bictegravir (ATC J05AR20) has antiviral properties. … Bictegravir
Products Docetaxel is commercially available as an infusion preparation (Taxotere, generics). It was approved in many countries in 1996 as a second taxane after paclitaxel (Taxol). Structure and properties Docetaxel (C43H53NO14, Mr = 807.9 g/mol) is present in the drug as docetaxel trihydrate, a white powder that is practically insoluble in water. The lipophilic drug … Docetaxel
Products Proton pump inhibitors (PPIs) are commercially available in many countries in the form of film-coated tablets, MUPS tablets, capsules, as granules for preparation of an oral suspension, and as injectable and infusion preparations. The first active ingredient from this group to be approved in many countries was omeprazole (Antra, Losec), developed by Astra in … Proton Pump Inhibitors
Products Palbociclib was approved in capsule form in the United States in 2015, in the EU in 2016, and in many countries in 2017 (Ibrance). Structure and properties Palbociclib (C24H29N7O2, Mr = 447.5 g/mol) is a pyridopyrimidine and exists as a yellow to orange powder. Effects Palbociclib (ATC L01XE33) has antitumor and antiproliferative properties. The … Palbociclib
