Products Direct oral anticoagulants (abbreviation: DOAKs) are commercially available in the form of film-coated tablets and capsules. By definition, they are oral drugs. Some representatives of the corresponding drug groups are also available as infusion preparations. Rivaroxaban (Xarelto) and dabigatran (Pradaxa) were the first active ingredients to be approved in 2008. The DOAKs were developed … DOAK
Products Dabigatran is commercially available in capsule form (Pradaxa). It has been approved in many countries since 2012. It was first approved in 2008. Structure and properties Dabigatran (C25H25N7O3, Mr = 471.5 g/mol) is present in drugs as mesilate and in the form of the prodrug dabigatran etexilate, which is metabolized in the organism by … Dabigatran
Symptoms The possible symptoms and signs of deep vein thrombosis include: Pain or cramping in the legs Swelling (edema), feeling of tension Warmth sensation, overheating Reddish to blue-purple discoloration of the skin Increased visibility of the superficial veins The symptoms are rather nonspecific. Deep vein thrombosis may also be asymptomatic and discovered by chance. A … Deep Vein Thrombosis
Products Direct factor Xa inhibitors are commercially available in the form of film-coated tablets and capsules. In 2008, rivaroxaban (Xarelto) was the first agent in this group to be approved in many countries and in the EU. Today, there are other drugs on the market, which are listed below. Like thrombin inhibitors, these active ingredients … Factor Xa Inhibitors
Chronic venous insufficiency results from a weakness of the veins. In this case, more and more blood accumulates in the leg veins, for example due to venous valves not closing properly. These veins dilate as a result. If this accumulation of blood persists, fluid can leak from the vessels. This causes water to accumulate in … Chronic venous insufficiency – You need to know that!
What stages are there? According to Widmer, chronic venous insufficiency is divided into three stages. The classification is based on the patient’s symptoms. In the first stage reversible water retention occurs. This means that the water retention, which manifests itself in the form of swelling of the legs, varies depending on the ambient temperature and … What stages are there? | Chronic venous insufficiency – You need to know that!
What can be long-term consequences? As a complication of chronic venous insufficiency, bleeding from the varicose veins, for example, can occur. This can be caused by the increased tension due to blood congestion or by an injury or accident. Often veins with a thin wall, which lie just under the skin, are affected. It then … What can be long-term consequences? | Chronic venous insufficiency – You need to know that!
What’s the prognosis? The duration and prognosis of chronic venous insufficiency depends on the stage of the disease. Especially in early stages, a rapid improvement of the symptoms can be seen with good therapy and conscious behaviour. Although more severe stages cannot usually be cured, much can be done to alleviate the symptoms. One of … What’s the prognosis? | Chronic venous insufficiency – You need to know that!
Products Betrixaban was approved in the United States in 2017 in capsule form (Bevyxxa). The drug has not yet been approved in the EU (Dexxience). Structure and properties Betrixaban (C23H22ClN5O3, Mr = 451.9 g/mol) is present in the drug as betrixaban maleate. It is a pyridine and anthranilamide derivative. Effects Betrixaban has antithrombotic properties. The … Betrixaban
Thrombosis and pill There are numerous factors that increase the risk of developing thrombosis. Especially the combination of different risk factors increases the risk. An important and frequent risk factor for women is the use of oral contraception, the so-called pill. Oral contraceptives are drugs taken mainly to prevent pregnancy and contain two active ingredients, … Thrombosis and pill | Thrombosis
Synonyms in a broader sense Deep vein thrombosis (DVT) Phlebothrombosis Venous thrombosis Pelvic vein thrombosis Venous thrombosis Blood Clot Leg vein thrombosis Lower leg thrombosis Economy class syndrome Tourist Class Syndrome Airplane thrombosis Definition Thrombosis A thrombosis is the clotting of blood (formation of a clot) in the blood vessel system, which leads to a … Thrombosis
CausesRisk factors There are many risk factors that increase the risk of thrombosis. It is the combination of different risk factors that increases the risk in particular. As safe factors of risk are considered: Operations (especially artificial hip joint and artificial knee joint) Overweight Smoking Gender (Women > Men) Lack of exercise (long-distance flights= economy … CausesRisk factors | Thrombosis
