Products Abiraterone is commercially available in the form of film-coated tablets (Zytiga). It has been approved in many countries since 2011. Structure and properties Abiraterone acetate (C26H33NO2, Mr = 391.5 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a prodrug and is rapidly biotransformed in the body to … Abiraterone Acetate
Products 5α-Reductase inhibitors are commercially available in many countries in the form of film-coated tablets and capsules. Finasteride was the first agent from this group to be approved in 1993 (USA: 1992). There are two finasteride drugs on the market. One with 5 mg for the treatment of prostate enlargement (Proscar, generic) and one with … 5Α-Reductase Inhibitors
Products Antiandrogens are mainly commercially available in the form of tablets, capsules, and injectables. Among the first steroidal agents was cyproterone acetate, which was patented in the 1960s. Flutamide was the first non-steroidal agent to be approved in the 1980s. Structure and properties A distinction is made between antiandrogens with a steroidal structure (like the … Antiandrogens
Products In many countries, no finished medicinal products containing alfatradiol are commercially available. In Germany, preparations for external use are available (e.g., Ell-Cranell). Structure and properties Alfatradiol (C18H24O2, Mr = 272.4 g/mol) or 17α-estradiol is a stereoisomer of the female sex hormone 17β-estradiol. Effects Alfatradiol inhibits the enzyme 5α-reductase, thereby inhibiting the synthesis of the … Alfatradiol
Symptoms Increasing diffuse thinning of the hair occurs in the area of the middle parting. In this case, unlike androgenetic alopecia in men, not all hair is lost, but the scalp becomes visible over time. Often, a densely hairy strip remains frontally above the forehead. Dense hair is also still found on the sides and … Androgenetic Alopecia in Women
Symptoms Hereditary hair loss in men begins at the temples (“receding hairline”) and continues to the crown and back of the head, with progressive thinning and the typical M-shaped pattern. Over time, all that may remain of the once lush head of hair is a bald spot and a crown of hair. Unlike telogen effluvium, … Androgenetic Alopecia in Men
Products Enzalutamide was initially registered in capsule form (Xtandi). Film-coated tablets were approved in many countries in 2019. They are smaller and therefore easier to take. Enzalutamide was approved in the United States in 2012 and in many countries and the EU in 2013. Structure and properties Enzalutamide (C21H16F4N4O2S, Mr = 464.4 g/mol) is an … Enzalutamide
Products Extracts from the fruits of saw palmetto are commercially available in many countries, mainly in the form of capsules. The medicinal drug is available in pharmacies and drugstores, but is rarely used. Stem plant The saw palmetto, a member of the palm family, is a small palm tree that grows to a maximum height … Saw Palmetto
Definition Increased body and facial hair in women corresponding to the male hair type due to androgen-induced conversion of vellus hair to terminal hair. Symptoms Excessive and altered hair growth (thick and pigmented) on the face, chest, abdomen, legs, buttocks, and back Acne Deeper voice Increased muscle mass Decrease in breast size Androgenetic alopecia Views … Hirsutism: Excessive Hair Growth
Products Clascoterone was approved as a cream in the United States in 2020 (Winlevi). Structure and properties Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water. Effects Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens … Clascoteron