Doxorubicin is a drug belonging to the anthracycline group of substances, which are used in chemotherapy as cytostatics to treat various types of cancer. The active ingredient belongs to the intercalants. What is doxorubicin? Doxorubicin is a cytostatic drug. Cytostatic drugs are substances that inhibit cell division and/or cell growth. Therefore, they are mainly used … Doxorubicin: Effects, Uses & Risks
Products Stavudine is commercially available in capsule form (Zerit). It has been approved in many countries since 1996. Structure and properties Stavudine (C10H12N2O4, Mr = 224.2 g/mol) is a thymidine analog with a missing 3′-hydroxy group. It is a prodrug that is biotransformed intracellularly to the active metabolite stavudine triphosphate. Stavudine exists as a white … Stavudine
Products Olaratumab was approved in the United States and EU in 2016 and in many countries in 2017 as a concentrate for the preparation of an infusion solution (Lartruvo). Structure and properties Olaratumab is a human IgG1 monoclonal antibody that binds to PDGFRα. It is produced by biotechnological methods and has a molecular weight of … Olaratumab
Products Trastuzumab is commercially available as a lyophilizate for preparation of an infusion concentrate (Herceptin, biosimilars). It has been approved in many countries since 1999 (US: 1998, EU: 2000). In 2016, an additional solution for subcutaneous injection for breast cancer therapy was released in many countries (Herceptin subcutaneous). It was available earlier in other countries. … Trastuzumab
Products Epirubicin is commercially available as a concentrate for injection/instillation (farmorubicin, generics). It has been approved in many countries since 1993. Structure and properties Epirubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to doxorubicin. Effects Epirubicin (ATC L01DB03) is antineoplastic. It is an anthracycline antibiotic, rapidly penetrates the cell, binds to DNA, and … Epirubicin
Products Doxorubicin is commercially available as an injectable (Adriblastin, generic). It has been approved in many countries since 1989. Caelyx is a pegylated and liposomal formulation of the drug and was registered in 1997. Myocet is a liposomal and nonpegylated formulation. Structure and properties Doxorubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to … Doxorubicin
P-glycoprotein P-glycoprotein (P-gp, MDR1) is a primary active efflux transporter with a molecular weight of 170 kDa, belonging to the ABC superfamily and consisting of 1280 amino acids. P-gp is the product of the -gene (formerly: ). P is for , ABC is for . Occurrence P-glycoprotein is found on various tissues of the human … P-Glycoprotein
Hand-foot syndrome occurs more frequently during treatment with cytostatic drugs. Patients’ feet and hands become red, scaly, and painful or are affected by sensory disturbances. Hand-foot syndrome is treated symptomatically with analgesics and creams. What is hand-foot syndrome? Therapeutic drug treatments are usually associated with various side effects and health risks. In particular, phenomena such … Hand-foot Syndrome: Causes, Symptoms & Treatment
In the context of radiology, transarterial chemoembolization (TACE) represents a minimally invasive procedure used to treat liver cancer that can no longer be operated on. In most cases, it can no longer cure liver cancer. However, it does help prolong the patient’s life. What is transarterial chemoembolization? With the help of transarterial chemoembolization (TACE), inoperable … Transarterial Chemoembolization: Treatment, Effects, & Risks
