Products Eribulin is commercially available as a solution for injection (Halaven). It was approved in many countries and in the EU in 2011. In the United States, it has been registered since 2010. Structure and properties Eribulin is present in drugs as eribulin mesilate (C40H59NO11 – CH4O3S, Mr = 826.0 g/mol), a white crystalline powder … Eribulin
Products Azilsartan has been approved in the United States and the EU in tablet form since 2011 (Edarbi). In many countries, it was registered in August 2012 as the 8th member of the sartan drug group. In 2014, a fixed combination with chlortalidone was approved (Edarbyclor). Structure Azilsartan (C25H20N4O5, Mr = 456.5 g/mol) is present … Azilsartan
Products Mitotane is commercially available in tablet form (Lysodren). It was approved in many countries in 2010. Structure and properties Mitotane or 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene (C14H10Cl4, Mr = 320.041 g/mol) is a derivative of an insecticide. Effects Mitotane (ATC L01XX23) has a cytotoxic effect on the adrenal glands and may also cause adrenal inhibition without cell destruction. … Mitotan
Products Indoxacarb is commercially available as a drop-on solution for dogs and cats. It was approved in many countries in July 2012. Structure and properties Indoxacarb (C22H17ClF3N3O7, Mr = 527.8 g/mol) is a prodrug that is biotransformed to the active metabolite only in the insect by cleavage of the carbomethoxy group. It belongs to the … Indoxacarb
Products Abiraterone is commercially available in the form of film-coated tablets (Zytiga). It has been approved in many countries since 2011. Structure and properties Abiraterone acetate (C26H33NO2, Mr = 391.5 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a prodrug and is rapidly biotransformed in the body to … Abiraterone Acetate
Background According to the Labor Law, shift work refers to employees working staggered and alternately at the same workplace: “Shift work occurs when two or more groups of employees are assigned to work staggered and alternately at the same workplace according to a specific schedule.” This definition also refers to work during the day. From … Night Work
Products Caspofungin must be administered as an infusion solution because of its low oral bioavailability (Cancidas, generics). It has been approved in many countries since 2002 and was the first member of the echinocandins. Structure and properties Caspofungin is present in drugs as caspofungin diacetate (C52H88N10O15 – 2C2H4O2, Mr = 1213.42 g/mol), a hygroscopic white … Caspofungin
Products Benfluorex was marketed in many countries as Mediaxal (150 mg, Servier) until 1998. Today, it is no longer on the market. In France and other European countries, it was available as Mediator, among other products. Its approval was not withdrawn in France until 2009, although the risk for cardiotoxic side effects of comparable drugs … Benfluorex
Products Benzalkonium chloride is commercially available as an active pharmaceutical ingredient in the form of lozenges, as a gargling solution, as a gel and as a disinfectant, among others. As a preservative, it is commonly added in pharmaceuticals to eye drops, nasal sprays, nose drops and inhalation solutions for asthma and COPD treatment. It is … Benzalkonium Chloride
Products Retigabine was approved in many countries as film-coated tablets since 2011 (Trobalt). In the United States, it is referred to as ezogabine. It was discontinued in 2017. Structure Retigabine (C16H18FN3O2, Mr = 303.3 g/mol) is a carbamate that was developed starting from the analgesic flupirtine. The free primary amino group is -glucuronidated (see below). … Retigabine (Ezogabine)
Products Pasireotide is commercially available as an injectable (Signifor, Signifor LAR). It was approved in the EU and many countries in 2012. Structure and properties Pasireotide (C59H67N9O9, Mr = 1046.2 g/mol) is present in the drug as pasireotide diaspartate or as pasireotide pamoate. It is a cyclohexapeptide and an analog of the hormone somatostatin. Somatostatin … Pasireotide
Products Preparations from blueberries are available in pharmacies and drugstores in the form of teas, capsules, and as juice, among others. The medicinal drug is available as an open commodity. Blueberries are a typical ingredient in wild berry jams. Stem plant Bilberry L. is a perennial, low-growing shrub of the heather family (Ericaceae) native to … Blueberries
