Products Filgrastim is commercially available as a solution for injection in vials and prefilled syringes (Neupogen, biosimilars). It has been approved in many countries since 1991. Structure and properties Filgrastim is a protein of 175 amino acids produced by biotechnology. The sequence corresponds to human granulocyte colony-stimulating factor (G-CSF, Mr = 18,800 Da) with the … Filgrastim
Products Pegfilgrastim is commercially available as a solution for injection in the form of prefilled syringes (Neulasta). It has been approved in many countries since 2003. Biosimilars have been approved. Structure and properties Pegfilgrastim is a conjugate of filgrastim with a single 20-kDa polyethylene glycol (PEG) molecule. Filgrastim is a protein of 175 amino acids … Pegfilgrastim
Products Lenograstim is commercially available as an injection/infusion preparation (Granocyte). It has been approved in many countries since 1993. Structure and properties Lenograstim is a protein of 174 amino acids produced by biotechnology. The sequence corresponds to human granulocyte colony-stimulating factor (G-CSF). Unlike filgrastim, lenograstim is identical to G-CSF and is glycosylated. Effects Lenograstim (ATC … Lenograstim
Symptoms Typical symptoms of agranulocytosis include fever, chills, feeling ill, tonsillitis, sore throat, difficulty swallowing, and lesions and bleeding of the oral, nasal, pharyngeal, genital, or anal mucosa. The disease can lead to dangerous infections and blood poisoning and, if left untreated, can relatively often be fatal. Agranulocytosis usually occurs rarely to very rarely as … Agranulocytosis Symptoms and Treatment
Products Biosimilars are copycat preparations of biotechnology-derived drugs (biologics) that have strong similarities to the originator drugs but that are not exactly the same. The similarity relates to biological activity, structure, function, purity and safety, among other things. Biosimilars differ from generics of small molecule drugs in important ways. Biosimilars are usually marketed as injection … Biosimilars
