Products Canrenone is commercially available as an injectable (Soldactone). It has been approved in many countries since 1975. Structure and properties Canrenone (C22H28O3, Mr = 340.5 g/mol) is an active metabolite of spironolactone (aldactone) and, unlike the latter, is soluble in water. Canrenone is present in drugs as potassium canrenoate, the potassium salt of canrenoic … Canrenon
Products Metyrapone is commercially available in the form of capsules (Metopiron). It has been approved in many countries since 1961. Structure and properties Metyrapone (C14H14N2O, Mr = 226.27 g/mol) is a pyridine derivative. It is a white to light amber crystalline powder that is sparingly soluble in water. Effects Metyrapone (ATC V04CD01) inhibits the synthesis … Metyrapon
Symptoms High blood pressure is often asymptomatic, meaning that no symptoms occur. Nonspecific symptoms such as headache, bleeding in the eye, nosebleeds, and dizziness are observed. In advanced disease, various organs such as the vessels, retina, heart, brain and kidney are affected. Hypertension is a known and important risk factor for atherosclerosis, dementia, cardiovascular diseases … Hypertension
Background Potassium ions play an important role in many biological processes, particularly in the generation of membrane and action potentials and electrical conduction in nerve cells and the heart. Potassium is 98% localized intracellularly. The primary active transporter Na+/K+-ATPase provides transport into cells. Two hormones maintain the deep extracellular potassium concentration. The first is insulin, … Hypokalemia (Low Potassium)
Products Fosinopril is commercially available in tablet form. It has been approved in many countries since 1991. The original fosinopril is no longer available. Only fixed combinations with hydrochlorothiazide are currently on the market (generics). Fosicomp is also off the market. Structure and properties Fosinopril (C30H46NO7P, Mr = 563.7 g/mol) is present in drugs as … Fosinopril
Introduction Systole is the ejection phase of the heart, i.e. the phase in which blood is pumped from the heart into the aorta and thus into the body. If the systole is “too high”, this is called the systolic blood pressure value, which is elevated. This is the higher of the two values (1st value) … Systole too high – Is that dangerous?
Causes of too high a systole with too low a diastole The clinical picture of isolated systolic hypertension is characterized by a relatively high systolic blood pressure value and a relatively low diastolic blood pressure value (e.g. 160/50 mmHg). Thus the blood pressure amplitude increases to pathological levels. There are two main causes for this … Causes of too high a systole with too low a diastole | Systole too high – Is that dangerous?
Diagnosis If there is an elevated systolic blood pressure, there are several treatment options: Since all medications are associated with severe side effects, patients should first try to improve their lifestyle before resorting to drug therapy. If the excessive systole is caused by an existing disease, such as hyperthyroidism, this disease must first be treated. … Diagnosis | Systole too high – Is that dangerous?
