Products Zoledronic acid is commercially available as an infusion preparation (Zometa, Aclasta, generics). It has been approved in many countries since 2000. Structure and properties Zoledronic acid (C5H10N2O7P2, Mr = 272.1 g/mol) is present in drugs as zoledronic acid monohydrate, a white crystalline powder that is sparingly soluble in water. It is an imidazole derivative … Zoledronic Acid
Products Oxiconazole was commercially available in the form of vaginal tablets (Oceral). It was approved in many countries since 1983. It was discontinued in 2017. Structure and properties Oxiconazole (C18H13Cl4N3O, Mr = 429.1 g/mol) is present in drugs as oxiconazole nitrate. It is an imidazole derivative. Effects Oxiconazole (ATC D01AC11, ATC G01AF17) has antifungal properties … Oxiconazole
Products Enilconazole is commercially available as an emulsion concentrate for animals. It has been approved in many countries since 1985. Structure and properties Enilconazole (C14H14Cl2N2O, Mr = 297.2 g/mol) is an imidazole derivative. Effects Enilconazole (ATCvet QD01AC90) has antifungal properties. Indications For the treatment of fungal diseases of the skin in horses, cattle, and dogs.
Products Dexmedetomidine is commercially available as a concentrate for the preparation of an infusion solution (Dexdor). It was approved in many countries in 2012. Structure and properties Dexmedetomidine (C13H16N2, Mr = 200.3 g/mol) is an imidazole derivative and the -enantiomer of medetomidine. It is structurally closely related to detomidine and is present in drugs as … Dexmedetomidine
Products Antazoline is fixed combination with tetryzoline in the form of eye drops commercially available (Spersallerg, Spersallerg SDU). It has been approved in many countries since 1967. Structure and properties Antazoline (C17H19N3, Mr = 265.35 g/mol) is present in drugs as antazoline hydrochloride, a white crystalline powder that is sparingly soluble in water. It is … Antazoline: Antihistamine
Products Cimicoxib is commercially available in the form of chewable tablets for dogs (Cimalgex). It has been approved in many countries since 2011. Structure and properties Cimicoxib (C16H13ClFN3O3S, Mr = 381.8 g/mol) is a chlorinated and fluorinated benzenesulfonamide and imidazole derivative. It has a V-shaped structure like other COX-2 inhibitors, which allows binding to the … Cimicoxib
Products BIA 10-2474 is in clinical development at the Portuguese pharmaceutical company Bial. It is not commercially available. Structure and properties BIA 10-2474 is the following urea and imidazole derivative: Effects BIA 10-2474 is a long-acting inhibitor of the enzyme FAAH (fatty acid amide hydrolase). This enzyme is involved in the breakdown of fatty acid … BIA 10-2474
Products Epinastine is commercially available in the form of eye drops (Relestat). It has been approved in many countries since 2004. Structure and properties Epinastine (C16H15N3, Mr = 249.31 g/mol) is present in drugs as epinastine hydrochloride. It is an azepine and imidazole derivative. Effects Epinastine (ATC S01GX10) has antihistamine, antiallergic, and mast cell stabilizing … Epinastine
Products Medetomidine is commercially available as an injection solution for animals. It has been approved in many countries since 1990. Structure and properties Medetomidine (C13H16N2, Mr = 200.3 g/mol) is an imidazole derivative that is structurally closely related to detomidine. Medetomidine is a racemate; the pure -enantiomer dexmedetomidine is also used. Effects Medetomidine (ATCvet QN05CM91) … Medetomidine
Products Econazole is commercially available as a cream, powder, pump spray, vaginal cream, and vaginal suppository (Pevaryl, Gyno-Pevaryl, Pevisone + triamcinolone acetonide). The active ingredient has been approved in many countries since 1974. Structure and properties The imidazole derivative econazole (C18H15Cl3N2O, Mr = 381.7 g/mol) is a white powder that is practically insoluble in water. … Econazole
Products Miconazole is available as a cream, miconazole mouth gel and shampoo, and commercially (e.g., Daktarin). It has been approved in many countries since 1972. This article refers to external therapy. See also under miconazole mouth gel and miconazole for nail fungus. The nail tincture for nail fungus treatment is no longer marketed in many … Miconazole
Products Miconazole was commercially available for the treatment of nail fungus as a tincture (Daktarin). The drug was approved in many countries since 1981. It was discontinued from distribution in 2020. Structure and properties Miconazole (C18H14Cl4N2O , Mr = 416.13 g/mol) is an imidazole derivative. It is not present in the tincture as the salt … Miconazole against Nail Fungus
