Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval
Products Trimipramine is commercially available in tablet and drop form (Surmontil, generic). It has been approved in many countries since 1962. Structure and properties Trimipramine (C20H26N2, Mr= 294.5 g/mol) is present in drugs as trimipramine mesilate or trimipramine maleate, a racemate and white crystalline powder that is sparingly soluble in water. It is structurally closely … Trimipramine
Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants
Products Clomipramine is commercially available as sustained-release tablets and coated tablets (Anafranil). It has been approved in many countries since 1966 (originally Geigy, later Novartis). The injection and infusion preparations are no longer marketed. Structure and properties Clomipramine (C19H23ClN2, Mr = 314.9 g/mol) is present in drugs as clomipramine hydrochloride, a white to pale yellow … Clomipramine
Products Most antidepressants are commercially available in the form of film-coated tablets. In addition, oral solutions (drops), meltable tablets, dispersible tablets, and injectables are also available, among others. The first representatives were developed in the 1950s. It was discovered that the antituberculosis drugs isoniazid and iproniazid (Marsilid, Roche) had antidepressant properties. Both agents are MAO … Antidepressants
Symptoms In enuresis nocturna, a child older than 5 years empties the bladder repeatedly at night without an organic or medical cause. It does not wake up when the bladder is full and therefore cannot go to the toilet. During the day, on the other hand, everything works normally. The problem is slightly more common … Bedwetting (Enuresis Nocturna)
Definition Active ingredients are the active components of a drug that are responsible for its pharmacological effects. Drugs may contain a single active ingredient, multiple active ingredients, or complex mixtures such as herbal extracts. In addition to the active ingredients, a drug contains various excipients that should be as pharmacologically inert as possible. The percentage … Pharmaceutical Active Ingredient
Products Amitriptyline is commercially available as film-coated tablets and capsules (Saroten, limbitrol + chlordiazepoxide). It has been approved in many countries since 1961. The distribution of tryptizole was discontinued in 2012. Structure and properties Amitriptyline (C20H23N, Mr = 277.4 g/mol) is present in drugs as amitriptyline hydrochloride, a white powder or colorless crystals that are … Amitriptyline: Tricyclic Antidepressant
Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment
Imipramine is a tricyclic antidepressant. The active ingredient belongs to the dibenzazepine class. What is imipramine? Imipramine is a tricyclic antidepressant. Imipramine is an antidepressant that was among the first reliable drugs of this type. Thus, the drug served as a precursor for a variety of other agents for the treatment of depression. Imipramine was … Imipramine: Effects, Uses & Risks
Products Imipramine was commercially available in the form of dragées (Tofranil). It was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). It was approved in many countries in 1958 as the first active ingredient in the tricyclic antidepressant group. In … Imipramine: Drug Effects, Side Effects, Dosage and Uses
Products Desipramine is no longer available as a drug in many countries. Pertofran dragées are out of commerce. Structure and properties Desipramine (C18H22N2, Mr = 266.4 g/mol) is the main active metabolite of imipramine (desmethylimipramine). It is present in drugs as desipramine hydrochloride, a white crystalline powder that is soluble in water. Effects Desipramine (ATC … Desipramine
